Transporters

Four fundamentally different classes of membrane-bound transport proteins exist in organisms: ion channels; transporters; aquaporins; and ATP-powered pumps. Transport proteins serve the function of moving other materials within an organism. Basically, there are two different types of transport proteins: those that carry molecules to "distant" locations (within a cell or an organism), and those that serve as gateways, carrying molecules across otherwise impermeable membranes[1]. One example of a specific transporter that plays a key role in the metabolism of many organisms is the sodium dependent glucose co-transporter (SGLT), for example. A protein highly abundant in kidneys, that serves renal glucose reabsorption, and therefore is of high interest as a target for the treatment of diabetes[2] (for example SGLT2 inhibitor Remogliflozin (Axon 1634)).


[1] J.M. Berg, J.L. Tymoczko, L. Stryer. Biochemistry, 2002, 5th edition.New York. W. H. Freeman.
[2] Remogliflozin etabonate, in a Novel Category of Selective Low-Affinity / High-Capacity Sodium Glucose Cotransporter (SGLT2) Inhibitors, Exhibits Antidiabetic Efficacy in Rodent Models. Y. Fujimori, K. Katsuno,I. Nakashima, Y. Ishikawa-Takemura, H. Fujikura, M. Isaji. J. Pharmacol. Exp. Ther. 2008, 327, 268–276.

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Axon ID Name Description From price
2936 NVS-ZP7-4 First-in-class ZIP7 inhibitor €155.00
2116 O-Desmethylvenlafaxine succinate Metabolite of Venlafaxine; SNRI €90.00
1563 ORG 25935 GlyT-1 inhibitor €90.00
1452 Paroxetine hydrochloride SSRI €75.00
2303 R 55 Retromer stabilizing pharmacological chaperone. Potential Alzheimer's therapeutic €95.00
1720 R-(-)-O-Desmethylvenlafaxine Metabolite of Venlafaxine; SNRI €125.00
1123 Radafaxine hydrochloride NDRI €95.00
1240 Reboxetine mesylate Noradrenaline reuptake inhibitor (NARI) €105.00
1634 Remogliflozin SGLT2 inhibitor €150.00
3222 Reversan Potent, selective and non-toxic MRP1 inhibitor €90.00
1721 S-(+)-O-Desmethylvenlafaxine Metabolite of Venlafaxine; SNRI €125.00
2751 SEA0400 Inhibitor of Na+/Ca2+ exchanger (NCX) €135.00
1300 Sertraline hydrochloride SSRI; Antidepressant €85.00
1236 SKF 83566 hydrobromide D1 antagonist €70.00
2387 SMI 481 First small-molecule inhibitor (SMI) of the yeast PITP Sec14 €80.00

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