NVP-BBD130 - BBD 130

Based on 20 reference(s) in Google Scholar 80 100 20

Axon 1520

CAS [853910-61-9]

MF C28H21N5O
MW 443.50

Purity: 99%
Moderately soluble in DMSO

NVP-BBD130

Description

Orally potent and selective dual PI3K/mTOR inhibitor; IC50 values to be 72, 2336, 201 and 382 nM for PI3K p110 α, β, δ and γ isoforms, respectively; inhibition of PI3K/mTOR pathway like NVP-BEZ235, BBD130 efficiently attenuates growth and proliferation of melanoma primary tumors and metastasis

R Marone et al. Targeting Melanoma with Dual Phosphoinositide 3-Kinase/Mammalian Target of Rapamycin Inhibitors. Mol. Cancer Res. 2009, 7(4), 601-613.

F Stauffer et al. Imidazo[4,5-c]quinolines as inhibitors of the PI3K/PKB-pathway. Bioorg. Med. Chem. Lett. 2008, 18, 1027-1030.

SM Maria, P Furet and F Stauffer. Discovery of novel anticancer therapeutics targeting the PI3K/Akt/mTOR pathway. Future Med. Chem. 2009, 1(1), 137-155.

Dual PI3K and mTOR kinase inhibitor

Chemical name

2-Methyl-2-[4-(3-methyl-2-oxo-8-pyridin-3ylethynyl-2,3-dihydro-imidazo[4,5-c]quinolin-1-yl)-phenyl]-propionitrile

Parent CAS No.

[853910-61-9]

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5 mg	€125.00	In Stock
25 mg	€425.00	In Stock

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NVP-BBD130 - BBD 130

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NVP-BBD130 - BBD 130

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