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Temsirolimus
- CCI 779 - Torisel
- Soluble in DMSO
- MF: C56H87NO16
- MW: 1030.29
Description
Temsirolimus is a rapamycin analogue and specific mTOR pathway inhibitor used to suppress mTORC1-dependent growth and survival signaling.
mTOR integrates nutrient, growth factor and energy signals to regulate protein synthesis, angiogenesis and cell proliferation. Temsirolimus is used as a reference compound for mTOR-dependent oncology and metabolism research.
Key Features
- Specific inhibitor of mTORC1 pathway signaling
- Rapamycin-derived small-molecule pharmacology
- Modulates cell growth and angiogenesis pathways
- Clinically validated renal cell carcinoma target biology
Applications
- mTOR signaling studies
- Cancer cell growth and survival assays
- Angiogenesis and metabolism research
- Targeted oncology pathway models
More Information
| Parent CAS No. | 162635-04-3 |
|---|---|
| Chemical Name | 42-[3-hydroxy-2-(hydroxymethyl)-2-methylpropanoate]-Rapamycin |
| extra_info | . |
| MFCD | MFCD00934421 |
| Short Description | mTOR inhibitor |
References
- X Wan et al. CCI-779 Inhibits rhabdomyosarcoma xenograft growth by an antiangiogenic mechanism linked to the targeting of mTOR/HIF-1alpha/VEGF signaling. Neoplasia 2006, 8(5), 394–401.
- D DelBufalo et al. Antiangiogenic potential of the mammalian target of rapamycin inhibitor temsirolimus. Cancer Res. 2006, 66(11), 5549–5554.
- GV Thomas et al. Hypoxia-inducible factor determines sensitivity to inhibitors of mTOR in kidney cancer. Nature Medicine 2006, 12(1), 122–127.
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