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Torin 1
- Limited soluble in DMSO
- MF: C35H28F3N5O2
- MW: 607.62
Description
Torin 1 is a highly potent, selective and ATP-competitive mTOR inhibitor with reported IC50 values of 2 nM for mTORC1 and 10 nM for mTORC2.
mTOR integrates nutrient, growth-factor and energy signals to control protein translation, autophagy, metabolism and cell growth. Torin 1 is widely used to achieve catalytic inhibition of both mTOR complexes and to distinguish mTOR kinase activity from rapamycin-sensitive effects.
Key Features
- ATP-competitive mTOR kinase inhibitor
- IC50: 2 nM for mTORC1 and 10 nM for mTORC2
- Inhibits both rapamycin-sensitive and rapamycin-insensitive mTOR outputs
- Highly selective over PI3K in cellular assays
Applications
- mTORC1 and mTORC2 signaling studies
- Autophagy and nutrient-sensing pathway research
- Protein translation and 4E-BP/S6K phosphorylation assays
- Cancer metabolism and cell-growth models
Note: Sold under license from Whitehead Institute for Biomedical Research.
More Information
| Parent CAS No. | 1222998-36-8 |
|---|---|
| Chemical Name | 1-(4-(4-propionylpiperazin-1-yl)-3-(trifluoromethyl)phenyl)-9-(quinolin-3-yl)benzo[h][1,6]naphthyridin-2(1H)-one |
| SMILES | N1(C2=CC=C(N3CCN(C(=O)CC)CC3)C(C(F)(F)F)=C2)C2=C(C=NC3=CC=C(C4=CC5C(N=C4)=CC=CC=5)C=C32)C=CC1=O |
| MFCD | N.A. |
| InChi | InChI=1S/C35H28F3N5O2/c1-2-32(44)42-15-13-41(14-16-42)31-11-9-26(19-28(31)35(36,37)38)43-33(45)12-8-24-20-40-30-10-7-22(18-27(30)34(24)43)25-17-23-5-3-4-6-29(23)39-21-25/h3-12,17-21H,2,13-16H2,1H3 |
| InChiKey | AKCRNFFTGXBONI-UHFFFAOYSA-N |
| CID | 49836027 |
| Short Description | mTOR inhibitor |
References
- Q Liu et al. Discovery of 1-(4-(4-Propionylpiperazin-1-yl)-3-(trifluoromethyl)phenyl)-9-(quinolin-3-yl)benzo[h][1,6]naphthyridin-2(1H)-one as a Highly Potent, Selective mTOR Inhibitor for the Treatment of Cancer. J. Med. Chem. 2010, 53(19), 7146–7155.
- Q Liu et al. Discovery of 9-(6-aminopyridin-3-yl)-1-(3-(trifluoromethyl)phenyl)benzo[h][1,6]naphthyridin-2(1H)-one (Torin2) as a potent, selective, and orally available (mTOR) inhibitor for treatment of cancer. J. Med. Chem. 2011, 54(5), 1473-1480.
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