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Torin 2
- Soluble in DMSO
- MF: C24H15F3N4O
- MW: 432.4
Description
Torin 2 is a potent, selective, orally available and ATP-competitive mTOR inhibitor with a reported IC50 value of 2.1 nM for mTORC1 and sub-nanomolar cellular mTOR pathway activity.
Torin 2 provides catalytic inhibition of mTOR signaling and is used to study cell growth, autophagy, metabolic control and mTOR-dependent oncology biology. Its potency and pathway coverage make it a valuable comparator to Torin 1 and rapamycin-like agents.
Key Features
- Potent ATP-competitive mTOR inhibitor
- Reported IC50: 2.1 nM for mTORC1
- Inhibits cellular mTOR activity with high potency
- Orally available research compound for mTOR pathway studies
Applications
- mTOR pathway pharmacology
- Autophagy and nutrient response assays
- Cell growth, metabolism and translation studies
- Oncology signaling and pathway-inhibition profiling
Note: Sold under license from Whitehead Institute for Biomedical Research.
More Information
| Parent CAS No. | 1223001-51-1 |
|---|---|
| Chemical Name | 9-(6-aminopyridin-3-yl)-1-(3-(trifluoromethyl)phenyl)benzo[h][1,6]naphthyridin-2(1H)-one |
| SMILES | C1(C2=CC=C(N)N=C2)=CC2=C3N(C4C=CC=C(C(F)(F)F)C=4)C(=O)C=CC3=CN=C2C=C1 |
| MFCD | N.A. |
| InChi | InChI=1S/C24H15F3N4O/c25-24(26,27)17-2-1-3-18(11-17)31-22(32)9-6-16-13-29-20-7-4-14(10-19(20)23(16)31)15-5-8-21(28)30-12-15/h1-13H,(H2,28,30) |
| InChiKey | GUXXEUUYCAYESJ-UHFFFAOYSA-N |
| CID | 51358113 |
| Short Description | mTOR inhibitor |
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