YM201636

Based on 20 reference(s) in Google Scholar 80 100 20

Axon 2607

CAS [371942-69-7]

MF C25H21N7O3
MW 467.48

  • Purity: 98%
  • Soluble in 0.1N HCl(aq) and DMSO
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YM201636

Description

Selective inhibitor of PIKfyve (type III PtdInsP kinase; IC50 value 33 nM) that blocks PtdIns(3,5)P2 production and disrupts endomembrane transport and retroviral budding and nearly 100-fold selective over p110α. However, YM201636 arrests basal and insulin-induced glucose influx in cultured adipocytes at low nano-molar concentrations (doses are significantly lower than the effective antiretroviral dose), likely by affecting a PIKfyve-unrelated target. Moreover, YM-201636 dysregulates autophagy and promotes neuronal cell death in primary hippocampal neurons in culture.

KEYWORDS: YM201636 | Supplier | PIKfyve inhibitor | YM 201636 | YM-201636 | CAS [371942-69-7] | [2309172-21-0] | [371933-96-9] | Phosphatidylinositol | PIKfyve | Inhibitor | Enzymes | type III PtdInsP kinase | Endomembrane transport | Retroviral budding | Glucose influx | Autophagy | Neuronal cell death | Primary hippocampal neurons

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The purity of Axon Ligands™ is confirmed by HPLC-MS, 1H-NMR and/or microanalysis. Analytical data are available upon request.

Caution: Axon Ligands™ are not fully tested. They are for research purposes only! Not for human consumption!

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