Selective inhibitor of PIKfyve (type III PtdInsP kinase; IC50 value 33 nM) that blocks PtdIns(3,5)P2 production and disrupts endomembrane transport and retroviral budding and nearly 100-fold selective over p110α. However, YM201636 arrests basal and insulin-induced glucose influx in cultured adipocytes at low nano-molar concentrations (doses are significantly lower than the effective antiretroviral dose), likely by affecting a PIKfyve-unrelated target. Moreover, YM-201636 dysregulates autophagy and promotes neuronal cell death in primary hippocampal neurons in culture.

KEYWORDS: YM201636 | Supplier | PIKfyve inhibitor | YM 201636 | YM-201636 | CAS [371942-69-7] | [2309172-21-0] | [371933-96-9] | Phosphatidylinositol | PIKfyve | Inhibitor | Enzymes | type III PtdInsP kinase | Endomembrane transport | Retroviral budding | Glucose influx | Autophagy | Neuronal cell death | Primary hippocampal neurons