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SMER 28
- Soluble in 0.1N HCl(aq) and DMSO
- MF: C11H10BrN3
- MW: 264.12
Description
Small molecule enhancer of rapamycin that enhances the clearance of mutant aggregate-prone proteins by autophagy in mammalian cell models of Huntington’s and Parkinson’s disease, independent of mTOR and Atg5 pathways. SMER28 also promotes reprogramming of fibroblasts (the conversion efficiency for adult tail-tip fibroblasts in particular) into neural stem cells, if combined with RG108 (Axon 1691) and Parnate.
More Information
| Parent CAS No. | 307538-42-7 |
|---|---|
| Chemical Name | N-allyl-6-bromoquinazolin-4-amine |
| SMILES | N1=C2C(C=C(Br)C=C2)=C(NCC=C)N=C1 |
| MFCD | N.A. |
| InChi | InChI=1S/C11H10BrN3/c1-2-5-13-11-9-6-8(12)3-4-10(9)14-7-15-11/h2-4,6-7H,1,5H2,(H,13,14,15) |
| InChiKey | BCPOLXUSCUFDGE-UHFFFAOYSA-N |
| CID | 1560402 |
| Short Description | Autophagy inducer; SMER |
References
- S Sarkar et al. Small molecules enhance autophagy and reduce toxicity in Huntington's disease models. Nat Chem Biol. 2007 Jun;3(6):331-8.
- Y Tian et al. A small-molecule enhancer of autophagy decreases levels of Abeta and APP-CTF via Atg5-dependent autophagy pathway. FASEB J. 2011 Jun;25(6):1934-42.
- S Nekova et al. Small molecule enhancers of rapamycin induce apoptosis in myeloma cells via GSK3A/B preferentially within a protective bone marrow microenvironment. Br J Haematol. 2014 Oct;167(2):272-4.
- M Zhang et al. harmacological Reprogramming of Fibroblasts into Neural Stem Cells by Signaling-Directed Transcriptional Activation. Cell Stem Cell. 2016 May 5;18(5):653-67.
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