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MHY 1485
- Soluble in DMSO
- MF: C17H21N7O4
- MW: 387.39
Description
MHY 1485 is an mTOR pathway activator that suppresses autophagic flux by interfering with autophagosome-lysosome fusion. It increases LC3-II accumulation and activates mTOR-dependent signaling in cellular models.
mTOR integrates nutrient, growth-factor and stress signals to regulate protein synthesis, autophagy, metabolism and cell growth. MHY 1485 is useful for probing the relationship between mTOR activation, lysosomal function and autophagy blockade.
Key Features
- mTOR signaling activator
- Inhibits autophagosome-lysosome fusion
- Increases LC3-II/LC3-I ratio without enhancing autophagic flux
- Useful for studying mTOR-autophagy crosstalk
Applications
- mTOR pathway research
- Autophagy and lysosomal flux assays
- Cell growth and nutrient signaling studies
- Stress response and cell-death pathway analysis
More Information
| Parent CAS No. | 326914-06-1 |
|---|---|
| Chemical Name | 4,6-dimorpholino-N-(4-nitrophenyl)-1,3,5-triazin-2-amine |
| SMILES | N1C(N2CCOCC2)=NC(N2CCOCC2)=NC=1NC1C=CC([N+]([O-])=O)=CC=1 |
| MFCD | N.A. |
| InChi | InChI=1S/C17H21N7O4/c25-24(26)14-3-1-13(2-4-14)18-15-19-16(22-5-9-27-10-6-22)21-17(20-15)23-7-11-28-12-8-23/h1-4H,5-12H2,(H,18,19,20,21) |
| InChiKey | MSSXBKQZZINCRI-UHFFFAOYSA-N |
| CID | 2834965 |
| Short Description | mTOR activator |
References
- Y.J. Choi et al. Inhibitory effect of mTOR activator MHY1485 on autophagy: suppression of lysosomal fusion. PLoS One. 2012;7(8):e43418.
- A. Agarwal et al. Syntheses of 2,4,6-trisubstituted triazines as antimalarial agents. Bioorg Med Chem Lett. 2005 Feb 1;15(3):531-3.
- H. Ojha et al. Quantitative structure activity relationship study of 2,4,6-trisubstituted-s-triazine derivatives as antimalarial inhibitors of Plasmodium falciparum dihydrofolate reductase. Chem Biol Drug Des. 2011 Jan;77(1):57-62.
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