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GDC-0084
- Paxalisib
- Soluble in DMSO
- MF: C18H22N8O2
- MW: 382.42
Description
GDC-0084 is a brain-penetrant inhibitor of PI3K and mTOR with Ki (app) values of 2 nM and 0.07 μM for PI3Kα and mTOR, respectively.
More Information
| Parent CAS No. | 1382979-44-3 |
|---|---|
| Chemical Name | 5-(6,6-Dimethyl-4-morpholino-8,9-dihydro-6H-[1,4]oxazino[3,4-e]purin-2-yl)pyrimidin-2-amine |
| SMILES | C12N=C3C(C)(C)OCCN3C=1N=C(C1C=NC(N)=NC=1)N=C2N1CCOCC1 |
| MFCD | MFCD30187522 |
| InChi | InChI=1S/C18H22N8O2/c1-18(2)16-22-12-14(25-3-6-27-7-4-25)23-13(11-9-20-17(19)21-10-11)24-15(12)26(16)5-8-28-18/h9-10H,3-8H2,1-2H3,(H2,19,20,21) |
| InChiKey | LGWACEZVCMBSKW-UHFFFAOYSA-N |
| CID | 57384863 |
| Short Description | PI3K/mTOR inhibitor |
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