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PIK 90
- Moderately soluble in DMSO with 0.1N HCl(aq)
- MF: C18H17N5O3
- MW: 351.36
Description
Potent and cell permeable PI3K inhibitor, with IC50 values (nM) of 11, 350, 18, and 58 for p110 α, β, γ and δ isoforms, low mTOR activity.
More Information
| Parent CAS No. | 677338-12-4 |
|---|---|
| Chemical Name | N-(7,8-Dimethoxy-2,3-dihydro-imidazo[1,2-c]quinazolin-5-yl)-nicotinamide |
| SMILES | C1C=C2C3=NCCN3C(NC(=O)C3C=NC=CC=3)=NC2=C(OC)C=1OC |
| MFCD | MFCD12546131 |
| InChi | InChI=1S/C18H17N5O3/c1-25-13-6-5-12-14(15(13)26-2)21-18(23-9-8-20-16(12)23)22-17(24)11-4-3-7-19-10-11/h3-7,10H,8-9H2,1-2H3,(H,21,22,24) |
| InChiKey | ZJAVHOMVDCMAMF-UHFFFAOYSA-N |
| CID | 135398491 |
| Short Description | PI3K p110α inhibitor |
References
- JS Chen et al. Characterization of structurally distinct, isoform-selective phosphoinositide 3′-kinase inhibitors in combination with radiation in the treatment of glioblastoma. Mol. Cancer Ther. 2008, 7, 841-850.
- ZA Knight et al. A Pharmacological Map of the PI3-K Family Defines a Role for p110α in Insulin Signaling. Cell 2006, 125, 733–747.
- C Chaussade et al. Evidence for functional redundancy of class IA PI3K isoforms in insulin signalling. Biochem J. 2007, 404(3), 449–458.
- S Kim et al. Insulin-like growth factor-1 regulates platelet activation through PI3-Kα isoform. Blood, 2007, 110(13), 4206-4213.
- List of publications using PIK 90 (Axon 1362) purchased from Axon Medchem
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