Serabelisib - MLN1117 | INK1117 | TAK-117

Based on 16 reference(s) in Google Scholar 8 10 16

Axon 4075

CAS [1268454-23-4]

MF C19H17N5O3
MW 363.37

  • Purity: 99%
  • Soluble in DMSO



Serabelisib is an orally bioavailable, PI3K p110α-isoform specific inhibitor with an in vitro IC50 of 15 nM, highly selective against other isoforms (p110β, p110γ and p110δ) and mTOR (no significant inhibitions at 1 μM concentration). It displayed significant efficacy in several PI3Kα mutant-specific preclinical mouse xenograft tumor models, and blocked signaling to Akt and inhibited growth of cancer cells harboring wild-type or mutated p110α.

Keywords: Serabelisib | PI3K inhibitor | MLN1117 | INK1117 | TAK-117 | CT-Sera | MLN-1117 | MLN 1117 | INK1117 | INK 1117 | TAK117 | TAK 117 | CT-SERA | CAS [1268454-23-4] | Phosphatidylinositol | PI3K | Inhibitor | Enzymes

PI3K p110α isoform specific inhibitor

Chemical name


Source information

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Parent CAS No.


The purity of Axon Ligands™ is confirmed by HPLC-MS, 1H-NMR and/or microanalysis. Analytical data are available upon request.

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