Your cart

There are no items in your shopping cart

Serabelisib - MLN1117 | INK1117 | TAK-117

Based on 16 reference(s) in Google Scholar 8 10 16

Axon 4075

CAS [1268454-23-4]

MF C19H17N5O3
MW 363.37

  • Purity: 99%
  • Soluble in DMSO

Serabelisib

Description

Serabelisib is an orally bioavailable, PI3K p110α-isoform specific inhibitor with an in vitro IC50 of 15 nM, highly selective against other isoforms (p110β, p110γ and p110δ) and mTOR (no significant inhibitions at 1 μM concentration). It displayed significant efficacy in several PI3Kα mutant-specific preclinical mouse xenograft tumor models, and blocked signaling to Akt and inhibited growth of cancer cells harboring wild-type or mutated p110α.

Keywords: Serabelisib | PI3K inhibitor | MLN1117 | INK1117 | TAK-117 | CT-Sera | MLN-1117 | MLN 1117 | INK1117 | INK 1117 | TAK117 | TAK 117 | CT-SERA | CAS [1268454-23-4] | Phosphatidylinositol | PI3K | Inhibitor | Enzymes

PI3K p110α isoform specific inhibitor

Chemical name

(6-(2-Aminobenzo[d]oxazol-5-yl)imidazo[1,2-a]pyridin-3-yl)(morpholino)methanone

Source information

Sold in collaboration with Chemietek

Parent CAS No.

[1268454-23-4]

Related Products

Axon ID Name Description From price
1281 BEZ 235 PI3K and mTOR tyrosine kinase inhibitor €50.00
1282 BAG 956 PI3K and PDPK1 inhibitor €95.00
1334 PIK 75 hydrochloride PI3K inhibitor (p110-α specific) €70.00
1362 PIK 90 PI3K inhibitor (p110-α specific) €85.00
1366 LY 294002 PI3K inhibitor €70.00
1377 GDC 0941 bismesylate PI3K inhibitor €80.00
1380 PI 103 hydrochloride PI3K inhibitor (p110 specific) €60.00
1417 TGX 221 PI3K inhibitor (p110 β specific) €70.00
1424 AS 252424 PI3K inhibitor (p110-γ specific) €85.00
1520 NVP-BBD130 Dual PI3K and mTOR kinase inhibitor €125.00
1596 GSK 2126458 Dual PI3K and mTOR inhibitor €50.00
1706 XL PI3K/mTOR inhibitor Dual PI3K and mTOR kinase inhibitor €120.00
1719 D 106669 Potent and selective PI3K inhibitor €85.00
1782 GDC 0980 Dual PI3K and mTOR inhibitor €80.00
1797 NVP-BKM120 Class I PI3K inhibitor €90.00
1807 PKI 587 Dual PI3K and mTOR inhibitor €90.00
1831 A 66 PI3K inhibitor (p110-α specific) €95.00
1855 PF 04691502 PI3K and mTOR tyrosine kinase inhibitor €90.00
1912 GSK 2636771 dihydrochloride PI3K inhibitor (p110 β specific) €105.00
2029 NVP-BGT226 Orally active dual PI3K/mTOR inhibitor €120.00
2039 CZC 24832 PI3K inhibitor (p110-γ specific) €95.00
2170 CAL 101 PI3K inhibitor (p110 δ specific) €95.00
2168 IC 87114 Potent and highly selective inhibitor of the PI3K p110δ €85.00
1436 AS 252424 bispotassium salt PI3K inhibitor (p110-γ specific) €95.00
2610 PDK1 inhibitor 2610 Dual PI3K/PDPK1 inhibitor; desmethyl analogue of Axon 1282 €125.00
2716 SAR405 PIK3C3/Vps34 inhibitor €90.00
2748 Autophinib PIK3C3/Vps34 inhibitor €120.00
2857 Acalisib PI3K inhibitor (p110 δ specific) €120.00
2869 LX2343 BACE 1 inhibitor €125.00
2925 Alpelisib PI3K inhibitor (p110-α specific) €90.00
2926 AZD6482 PI3K inhibitor (p110 β specific) €120.00
2927 Taselisib PI3K inhibitor (p110 β sparing) €90.00
2994 GNE 317 Brain-penetrant PI3K inhibitor (p110-α specific) €85.00
3045 PI 3065 PI3K inhibitor (p110 δ specific) €100.00
3055 B591 Potent, specific class I PI3K inhibitor €125.00
3098 ME-401 Potent, selective and orally available PI3K inhibitor (p110 δ specific) €100.00
3247 Miltefosine PI3K/Akt inhibitor €50.00
3268 Metapristone Metabolite of Mifepristone (Axon 1502); PI3K/AKT inhibitor €110.00
3690 AZD8186 PI3Kβ/δ isoform-selective inhibitor Inquire
3807 GS-9901 Potent and isoform-selective inhibitor of PI3Kδ Inquire
3808 AZD3458 Orally bioavailable potent and selective PI3Kγ inhibitor Inquire
3794 Urolithin A Inhibitor of the PI3K/AKT/mTOR pathway €70.00
3827 AMG-511 Orally bioavailable, highly potent and selective pan-class I phosphatidylinositol-3 kinase (PI3K) inhibitor Inquire
3942 BAY-1082439 PI3Kα/β-balanced inhibitor Inquire
3974 TG100-115 PI3K P110 ץ/δ isoform-selective inhibitor Inquire
4009 XL-765 Potent and selective PI3K / mTOC inhibitor Inquire
4031 XL-147 PI3K (α, β, γ, δ) inhibitor Inquire
3792 PITCOIN3 Potent, highly selective and cell-permeable PI3KC2α inhibitor €210.00
4133 IPI-145 PI3K p110α/γ isoform specific inhibitor Inquire
4172 PITCOIN4 Potent and highly selective PI3KC2α inhibitor  Recently added €220.00

The purity of Axon Ligands™ is confirmed by HPLC-MS, 1H-NMR and/or microanalysis. Analytical data are available upon request.

Caution: Axon Ligands™ are not fully tested. They are for research purposes only! Not for human consumption!

Newsletter
Give Feedback
 
Send E-mail

Customer Support

About Axon Medchem

Download Product Catalog

Download the Axon Ligands™ catalogue 2021 Spring Edition

Follow Us

© 2016 Axon Medchem. All Rights Reserved.

Send us a message

×

Contact Us

* Required Fields

Please wait...