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D 106669
- Soluble in DMSO
- MF: C17H18N6O
- MW: 322.36
Description
D 106669 is a highly potent and selective class I PI3K inhibitor with reported PI3Kα IC50 below 10 nM.
Class I PI3K signaling controls Akt activation, growth factor responses and oncogenic survival. D 106669 is useful for studying PI3K pathway blockade and was reported to show activity in an A549 lung cancer xenograft model.
Key Features
- Potent class I PI3K inhibitor
- PI3Kα IC50 reported below 10 nM
- High selectivity over most tyrosine and serine/threonine kinases
- Reported activity in A549 lung cancer xenograft models
Applications
- PI3K/Akt pathway research
- Cancer cell signaling assays
- Kinase selectivity profiling
- In vivo pharmacology model interpretation
More Information
| Parent CAS No. | 938444-93-0 |
|---|---|
| Chemical Name | 1-ethyl-3-(3-(p-tolylamino)pyrido[2,3-b]pyrazin-6-yl)urea |
| SMILES | C1C=C2N=CC(NC3C=CC(C)=CC=3)=NC2=NC=1NC(=O)NCC |
| MFCD | MFCD17169985 |
| InChi | InChI=1S/C17H18N6O/c1-3-18-17(24)23-14-9-8-13-16(21-14)22-15(10-19-13)20-12-6-4-11(2)5-7-12/h4-10H,3H2,1-2H3,(H3,18,20,21,22,23,24) |
| InChiKey | RQBRFKKFZPOBFG-UHFFFAOYSA-N |
| CID | 16048654 |
| Short Description | PI3K inhibitor |
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