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XL PI3K/mTOR inhibitor
- Moderately soluble in DMSO
- MF: C31H29N5O6S
- MW: 599.66
Description
XL PI3K/mTOR inhibitor is an orally active dual PI3K/mTOR pathway inhibitor matching the pharmacological profile of XL 765.
PI3K and mTOR signaling regulate growth, metabolism, survival and therapeutic resistance. XL PI3K/mTOR inhibitor is useful for studying coordinated inhibition of class I PI3K and mTOR signaling in cancer and metabolic pathway models.
Key Features
- Dual PI3K/mTOR pathway inhibitor profile
- Orally active small-molecule kinase pharmacology
- Targets central growth and survival signaling nodes
- Useful for studying PI3K pathway feedback and resistance
Applications
- PI3K/mTOR signaling research
- Cancer cell growth and survival assays
- Pathway feedback and combination studies
- Kinase inhibitor profiling
Note: XL 765 has an updated CAS registry number [934493-76-2].
More Information
| Parent CAS No. | 934529-30-3 |
|---|---|
| Chemical Name | N-(3-(N-(3-(3,5-dimethoxyphenylamino)quinoxalin-2-yl)sulfamoyl)phenyl)-3-methoxy-4-methylbenzamide |
| SMILES | C1C=C2N=C(NC3C=C(OC)C=C(OC)C=3)C(NS(=O)(=O)C3C=C(NC(C4C=C(OC)C(C)=CC=4)=O)C=CC=3)=NC2=CC=1 |
| MFCD | N.A. |
| InChi | InChI=1S/C31H29N5O6S/c1-19-12-13-20(14-28(19)42-4)31(37)33-21-8-7-9-25(17-21)43(38,39)36-30-29(34-26-10-5-6-11-27(26)35-30)32-22-15-23(40-2)18-24(16-22)41-3/h5-18H,1-4H3,(H,32,34)(H,33,37)(H,35,36) |
| InChiKey | KEDAVYHDQWPBEY-UHFFFAOYSA-N |
| CID | 53483920 |
| Short Description | PI3K/mTOR inhibitor |
References
- C Garcia-Echeverria and WR Sellers. Drug discovery approaches targeting the PI3K/Akt pathway in cancer. Oncogene. 2008, 27(41), 5511-5526.
- W Gordon et al. Inhibitors of phosphatidylinositol 3-kinases: The next wave of anti-cancer drugs? Chem. New Zealand. 2009, 9-11.
- SM Maria, P Furet and F Stauffer. Discovery of novel anticancer therapeutics targeting the PI3K/Akt/mTOR pathway. Future Med. Chem. 2009, 1(1), 137-155.
- E Vilar et al. Pushing the envelope in the mTOR pathway: the second generation of inhibitors. Mol. Cancer Ther. 2011, 10(3), 395-403.
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