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AS 252424
- Soluble in 0.1N NaOH(aq) and DMSO
- MF: C14H8FNO4S
- MW: 305.28
Description
Potent and selective PI3K p110γ inhibitor; IC50 values for inhibition of human recombinant PI3Kγ, α, β, and δ are 30, 940, 20,000, and 20,000 nM respectively. A water-soluble bispotassium salt form of AS 252424 is available as well (Axon 1436).
More Information
| Parent CAS No. | 900515-16-4 |
|---|---|
| Chemical Name | 5-[1-[5-(4-Fluoro-2-hydroxy-phenyl)-furan-2-yl]-meth-(Z)-ylidene]-thiazolidine-2,4-dione |
| SMILES | C1C(C2OC(/C=C3SC(=O)NC3=O)=CC=2)=C(O)C=C(F)C=1 |
| MFCD | MFCD12024675 |
| InChi | InChI=1S/C14H8FNO4S/c15-7-1-3-9(10(17)5-7)11-4-2-8(20-11)6-12-13(18)16-14(19)21-12/h1-6,17H,(H,16,18,19)/b12-6- |
| InChiKey | OYYVWNDMOQPMGE-SDQBBNPISA-N |
| CID | 11630874 |
| Short Description | PI3K p110γ inhibitor |
References
- V Pomel et al. Furan-2-ylmethylene thiazolidinediones as novel, potent, and selective inhibitors of phosphoinositide 3-kinase gamma. J. Med. Chem. 2006, 49, 3857-3871.
- T Rückle et al. PI3Kγ inhibition: Towards an 'aspirin of the 21st century'?. Nature Reviews Drug Discovery 2006, 5, 903-918.
- BT Hennessy et al. Exploiting the PI3K/AKT pathway for cancer drug discovery.Nat. Rev. Drug Discov. 2005,4, 988-1004.
- AM Condliffe et al. Sequential activation of class IB and class IA PI3K is important for the primed respiratory burst of human but not murine neutrophils. Blood 2005, 106, 1432-1440.
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