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AS 252424 bispotassium salt
- AS 252424K
- Parent CAS: 900515-16-4
- Soluble in water and DMSO
- MF: C14H6FNO4S.K2
- MW: 381.46
Description
Potent and selective PI3K p110γ inhibitor; IC50 values for inhibition of human recombinant PI3Kγ, α, β, and δ to be 30, 940, 20,000, and 20,000 nM respectively; water-soluble bispotassium salt form of AS 252424 (Axon 1424).
More Information
| Parent CAS No. | 900515-16-4 |
|---|---|
| Chemical Name | Bispotassium 5-[1-[5-(4-Fluoro-2-hydroxy-phenyl)-furan-2-yl]-meth-(Z)-ylidene]-thiazolidine-2,4-dione |
| SMILES | S1/C(=CC2=CC=C(C3=CC=C(F)C=C3[O-])O2)/C(=O)[N-]C1=O.[K+].[K+] |
| MFCD | N.A. |
| InChi | InChI=1S/C14H8FNO4S.2K/c15-7-1-3-9(10(17)5-7)11-4-2-8(20-11)6-12-13(18)16-14(19)21-12;;/h1-6H,(H2,16,17,18,19);;/q;2*+1/p-2 |
| InChiKey | HOZALNBQFGRKDW-UHFFFAOYSA-L |
| CID | 91826464 |
| Short Description | PI3K p110γ inhibitor |
References
- V. Pomel et al. Furan-2-ylmethylene thiazolidinediones as novel, potent, and selective inhibitors of phosphoinositide 3-kinase gamma. J. Med. Chem. 2006, 49, 3857-3871.
- T. Rückle et al. PI3Kgamma inhibition: towards an 'aspirin of the 21st century'? Nat. Rev. Drug Discov. 2006, 5, 903-918.
- B.T. Hennessy et al. Exploiting the PI3K/AKT pathway for cancer drug discovery. Nat. Rev. Drug Discov. 2005, 4, 988-1004.
- A.M. Condliffe et al. Sequential activation of class IB and class IA PI3K is important for the primed respiratory burst of human but not murine neutrophils. Blood. 2005, 106, 1432-1440.
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