Bulk Inquiry
VE 822
- Berzosertib - VX 970
- Soluble in 0.1N HCl(aq) and DMSO
- MF: C24H25N5O3S
- MW: 463.55
Description
VE 822 (Berzosertib) is a selective inhibitor of ATR kinase, a core regulator of replication-stress and DNA-damage checkpoint signaling. It sensitizes cancer cells to DNA damage by weakening checkpoint maintenance and homologous recombination responses.
ATR coordinates cell-cycle arrest, replication fork stability and repair signaling after DNA damage or replication stress. VE 822 is a valuable tool for studying DNA-damage response pharmacology and combination strategies with radiation or genotoxic agents.
Key Features
- Selective ATR kinase inhibitor
- Reported IC50 values: 0.019 µM for ATR, 2.6 µM for ATM and 18.1 µM for DNA-PK
- Disrupts checkpoint maintenance and homologous recombination after irradiation
- Enhances sensitivity to DNA-damaging treatments in cancer models
Applications
- DNA-damage response research
- ATR checkpoint signaling assays
- Radiosensitization and combination-treatment studies
- Cancer cell replication-stress models
More Information
| Parent CAS No. | 1232416-25-9 |
|---|---|
| Chemical Name | 5-(4-(isopropylsulfonyl)phenyl)-3-(3-(4-((methylamino)methyl)phenyl)isoxazol-5-yl)pyrazin-2-amine |
| SMILES | C1(N)=NC=C(C2=CC=C(S(C(C)C)(=O)=O)C=C2)N=C1C1ON=C(C2=CC=C(CNC)C=C2)C=1 |
| MFCD | N.A. |
| InChi | InChI=1S/C24H25N5O3S/c1-15(2)33(30,31)19-10-8-18(9-11-19)21-14-27-24(25)23(28-21)22-12-20(29-32-22)17-6-4-16(5-7-17)13-26-3/h4-12,14-15,26H,13H2,1-3H3,(H2,25,27) |
| InChiKey | JZCWLJDSIRUGIN-UHFFFAOYSA-N |
| CID | 59472121 |
| Short Description | ATR inhibitor |
Related Products
| AXON ID | NAME | FROM PRICE |
|---|---|---|
| 1281 | BEZ 235 |
From $55.00 |
| 1282 | BAG 956 |
From $104.50 |
| 1334 | PIK 75 hydrochloride |
From $77.00 |
| 1362 | PIK 90 |
From $93.50 |
| 1366 | LY 294002 |
From $77.00 |
| 1367 | KU-55933 |
From $121.00 |
| 1377 | GDC 0941 bismesylate |
From $88.00 |
| 1380 | PI 103 hydrochloride |
From $66.00 |
| 1417 | TGX 221 |
From $77.00 |
| 1424 | AS 252424 |
From $93.50 |
| 1436 | AS 252424 bispotassium salt |
From $104.50 |
| 1463 | NU 7441 |
From $44.00 |
| 1495 | CP 466722 |
From $77.00 |
| 1520 | NVP-BBD130 |
From $137.50 |
| 1596 | GSK 2126458 |
From $55.00 |
| 1706 | XL PI3K/mTOR inhibitor |
From $132.00 |
| 1719 | D 106669 |
From $93.50 |
| 1782 | GDC 0980 |
From $88.00 |
| 1797 | NVP-BKM120 |
From $99.00 |
| 1807 | PKI 587 |
From $99.00 |
| 1831 | A 66 |
From $104.50 |
| 1855 | PF 04691502 |
From $99.00 |
| 1893 | VE 821 |
From $88.00 |
| 1912 | GSK 2636771 dihydrochloride |
From $115.50 |
