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Taselisib
- GDC 0032 - RG 7604
- Soluble in DMSO
- MF: C24H28N8O2
- MW: 460.53
Description
Taselisib is a β-sparing PI3K inhibitor with Ki values of 0.29, 0.12 and 0.97 nM for PI3Kα, PI3Kδ and PI3Kγ, respectively. Moreover, Taselisib showed improved unbound drug exposure and effectively suppressed growth of tumors in a mouse xenograft model at low drug dose levels.
More Information
| Parent CAS No. | 1282512-48-4 |
|---|---|
| Chemical Name | 2-(4-(2-(1-Isopropyl-3-methyl-1H-1,2,4-triazol-5-yl)-5,6-dihydrobenzo[f]imidazo[1,2-d][1,4]oxazepin-9-yl)-1H-pyrazol-1-yl)-2-methylpropanamide |
| SMILES | C1(C2=CN(C(C(=O)N)(C)C)N=C2)C=C2OCCN3C=C(C4=NC(C)=NN4C(C)C)N=C3C2=CC=1 |
| MFCD | N.A. |
| InChi | InChI=1S/C24H28N8O2/c1-14(2)32-22(27-15(3)29-32)19-13-30-8-9-34-20-10-16(6-7-18(20)21(30)28-19)17-11-26-31(12-17)24(4,5)23(25)33/h6-7,10-14H,8-9H2,1-5H3,(H2,25,33) |
| InChiKey | BEUQXVWXFDOSAQ-UHFFFAOYSA-N |
| CID | 51001932 |
| Short Description | PI3K inhibitor |
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