PDK1 inhibitor 2610

Based on 20 reference(s) in Google Scholar 80 100 20

Axon 2610

CAS [2108463-93-8]

MF C25H15N5.HCl
MW 421.88

Purity: 99%
Soluble in water and DMSO

PDK1 inhibitor 2610

Description

Potent, ATP-competitive and selective dual PI3K and PDPK1 inhibitor (IC50 values 34 nM and 94 nM for PDK1 and p-T308-PKB inhibition, respectively. Also inhibits PI3K p110α, p110β, p110δ, and p110γ (IC50 values 64 nM, 432 nM , 98 nM, and 67 nM, respectively).

Axon 2610 is a close analogue of NVP-BAG956 (Axon 1282)

KEYWORDS: PDK1 inhibitor 2610 | supplier | PI3K/PDK1 inhibitor | CAS [2108463-93-8],[853909-77-0] | Phosphatidylinositol | PI3K | PDPK | Inhibitor | PKB | Akt | p110 | Oncology | PIP3 | Novartis

F Stauffer et al. Imidazo[4,5-c]quinolines as inhibitors of the PI3K/PKB-pathway. Bioorg Med Chem Lett. 2008 Feb 1;18(3):1027-30.

ST Murphy et al. Discovery of novel, potent, and selective inhibitors of 3-phosphoinositide-dependent kinase (PDK1). J Med Chem. 2011 Dec 22;54(24):8490-500.

Dual PI3K/PDPK1 inhibitor; desmethyl analogue of Axon 1282

Chemical name

2-(4-(8-(pyridin-3-ylethynyl)-1H-imidazo[4,5-c]quinolin-1-yl)phenyl)acetonitrile hydrochloride

Parent CAS No.

[853909-77-0]

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25 mg	€435.00	In Stock

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