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PDK1 inhibitor 2610
- Parent CAS: 853909-77-0
- Soluble in water and DMSO
- MF: C25H15N5.HCl
- MW: 421.88
Description
Potent, ATP-competitive and selective dual PI3K and PDPK1 inhibitor (IC50 values 34 nM and 94 nM for PDK1 and p-T308-PKB inhibition, respectively. Also inhibits PI3K p110α, p110β, p110δ, and p110γ (IC50 values 64 nM, 432 nM , 98 nM, and 67 nM, respectively).
Axon 2610 is a close analogue of NVP-BAG956 (Axon 1282)
More Information
| Parent CAS No. | 853909-77-0 |
|---|---|
| Chemical Name | 2-(4-(8-(pyridin-3-ylethynyl)-1H-imidazo[4,5-c]quinolin-1-yl)phenyl)acetonitrile hydrochloride |
| SMILES | C1(CC#N)=CC=C(N2C3C4C(N=CC=3N=C2)=CC=C(C#CC2=CC=CN=C2)C=4)C=C1.Cl |
| MFCD | N.A. |
| InChi | InChI=1S/C25H15N5.ClH/c26-12-11-18-5-8-21(9-6-18)30-17-29-24-16-28-23-10-7-19(14-22(23)25(24)30)3-4-20-2-1-13-27-15-20;/h1-2,5-10,13-17H,11H2;1H |
| InChiKey | RUXNLVOZJZTQAS-UHFFFAOYSA-N |
| CID | 122129988 |
| Short Description | PI3K/PDK1 inhibitor |
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