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PS 48
- Soluble in DMSO and EtOH
- MF: C17H15ClO2
- MW: 286.75
Description
PS 48 is an allosteric phosphoinositide-dependent protein kinase 1 (PDK1/PDPK1) activator that modulates PI3K-dependent kinase signaling.
PDK1 phosphorylates and activates AGC kinases including Akt, SGK and PKC family members. PS 48 is useful for probing PDK1 activation mechanisms, downstream Akt pathway signaling and cellular responses to enhanced PI3K/PDK1 activity.
Key Features
- Allosteric activator of PDK1/PDPK1
- Modulates PI3K-dependent AGC kinase signaling
- Z-isomer with activity distinct from inactive PS 47
- Useful probe for kinase activation studies
Applications
- PDK1 activation assays
- PI3K/Akt pathway research
- AGC kinase signaling studies
- Cell survival and metabolism models
Note: PS 48 has a Z-configuration; the inactive E-isomer PS 47 is available as Axon 1664.
More Information
| Parent CAS No. | 1180676-32-7 |
|---|---|
| Chemical Name | (Z)-5-(4-chlorophenyl)-3-phenylpent-2-enoic acid |
| SMILES | C1C=C(CC/C(=C/C(=O)O)/C2C=CC=CC=2)C=CC=1Cl |
| MFCD | MFCD17215962 |
| InChi | InChI=1S/C17H15ClO2/c18-16-10-7-13(8-11-16)6-9-15(12-17(19)20)14-4-2-1-3-5-14/h1-5,7-8,10-12H,6,9H2,(H,19,20)/b15-12- |
| InChiKey | LLJYFDRQFPQGNY-QINSGFPZSA-N |
| CID | 44141940 |
| Short Description | PDK1 activator |
References
- A Stroba et al. 3,5-Diphenylpent-2-enoic acids as allosteric activators of the protein kinase PDK1: structure-activity relationships and thermodynamic characterization of binding as paradigms for PIF-binding (...). J. Med. Chem. 2009, 52(15), 4683-93.
- V Hindie et al. Structure and allosteric effects of low-molecular-weight activators on the protein kinase PDK1. Nature Chem. Biol. 2009, 5, 758-764.
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