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SMI 481
- 6748-481
Axon 2387
CAS:
432020-20-7
Purity:
99%
- Soluble in DMSO
- MF: C17H15ClFN3O3
- MW: 363.77
Description
SMI 481 is a small-molecule inhibitor of the yeast phosphatidylinositol transfer protein (PITP) Sec14 with IC50 values of 211 nM for Sec14-mediated [3H]PtdIns transfer and 2.87 μM for Sec14-dependent cell growth inhibition. It shows pathway-selective inhibition of phosphoinositide signaling in cells.
Sec14-like phosphatidylinositol transfer proteins regulate lipid exchange and phosphoinositide signaling. SMI 481 is useful for investigating PITP-directed small molecules and lipid-transfer-dependent cellular signaling.
Key Features
- Sec14 phosphatidylinositol transfer protein (PITP) inhibitor
- IC50: 211 nM for Sec14-mediated PtdIns transfer
- Inhibits Sec14-dependent cell growth
- Selective over other yeast Sec14-like transfer activities in reported assays
Applications
- PITP/Sec14 pharmacology
- Phosphoinositide signaling studies
- Lipid-transfer protein assays
- Chemical genetics of membrane lipid signaling
More Information
| Parent CAS No. | 432020-20-7 |
|---|---|
| Chemical Name | (4-chloro-3-nitrophenyl)(4-(2-fluorophenyl)piperazin-1-yl)methanone |
| SMILES | C1C(F)=C(N2CCN(C(=O)C3C=CC(Cl)=C([N+]([O-])=O)C=3)CC2)C=CC=1 |
| MFCD | N.A. |
| InChi | InChI=1S/C17H15ClFN3O3/c18-13-6-5-12(11-16(13)22(24)25)17(23)21-9-7-20(8-10-21)15-4-2-1-3-14(15)19/h1-6,11H,7-10H2 |
| InChiKey | LSPJXCGEFJDMHA-UHFFFAOYSA-N |
| CID | 1334619 |
| Short Description | PITP Sec14 inhibitor |
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