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Palomid 529
- SG 00529
- Soluble in DMSO
- MF: C24H22O6
- MW: 406.43
Description
More Information
| Parent CAS No. | 914913-88-5 |
|---|---|
| Chemical Name | 8-(1-hydroxyethyl)-2-methoxy-3-(4-methoxybenzyloxy)-6H-benzo[c]chromen-6-one |
| SMILES | C1C=C2C3C=C(OC)C(OCC4C=CC(OC)=CC=4)=CC=3OC(=O)C2=CC=1C(O)C |
| MFCD | N.A. |
| InChi | InChI=1S/C24H22O6/c1-14(25)16-6-9-18-19-11-22(28-3)23(12-21(19)30-24(26)20(18)10-16)29-13-15-4-7-17(27-2)8-5-15/h4-12,14,25H,13H2,1-3H3 |
| InChiKey | YEAHTLOYHVWAKW-UHFFFAOYSA-N |
| CID | 11998575 |
| Short Description | Akt/mTOR inhibitor |
References
- Q Xue et al. Palomid 529, a Novel Small-Molecule Drug, Is a TORC1/TORC2 Inhibitor That Reduces Tumor Growth, Tumor Angiogenesis, and Vascular Permeability. Cancer Res. 2008, 68(22), 9551-9557.
- R Diaz et al. The novel Akt inhibitor Palomid 529 (P529) enhances the effect of radiotherapy in prostate cancer. Br. J. Cancer 2009, 100, 932–940.
- GL Gravina et al. The TORC1/TORC2 inhibitor, Palomid 529, reduces tumor growth and sensitizes to docetaxel and cisplatin in aggressive and hormone-refractory prostate cancer cells. Endocr. Relat. Cancer. 2011, 18(4), 385-400.
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