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CP 466722
- Soluble in DMSO
- MF: C17H15N7O2
- MW: 349.35
Description
CP 466722 is a selective and reversible inhibitor of ataxia-telangiectasia mutated (ATM) kinase. It suppresses ATM-dependent phosphorylation events initiated by DNA double-strand breaks while showing limited activity against related PI3K-like kinases in cellular assays.
The rapid reversibility of CP 466722 makes it useful for temporally controlled studies of ATM signaling. Inhibition of ATM disrupts DNA-damage checkpoints and can increase sensitivity to ionizing radiation and other genotoxic treatments.
Key Features
- Selective, reversible ATM kinase inhibitor
- Blocks ATM-dependent DNA-damage signaling
- Enables temporal control of ATM pathway inhibition
- Induces checkpoint defects and radiosensitization
Applications
- ATM kinase and DNA double-strand-break research
- Cell-cycle checkpoint studies
- Radiation-response and radiosensitization experiments
- DNA-damage repair and synthetic-lethality models
More Information
| Parent CAS No. | 1080622-86-1 |
|---|---|
| Chemical Name | 2-(6,7-Dimethoxy-quinazolin-4-yl)-5-pyridin-2-yl-2H-[1,2,4]triazol-3-ylamine |
| SMILES | C1(C2=NN(C(N)=N2)C2=NC=NC3C2=CC(OC)=C(OC)C=3)N=CC=CC=1 |
| MFCD | MFCD17392566 |
| InChi | InChI=1S/C17H15N7O2/c1-25-13-7-10-12(8-14(13)26-2)20-9-21-16(10)24-17(18)22-15(23-24)11-5-3-4-6-19-11/h3-9H,1-2H3,(H2,18,22,23) |
| InChiKey | ILBRKJBKDGCSCB-UHFFFAOYSA-N |
| CID | 44551660 |
| Short Description | ATM inhibitor |
References
- MD Rainey et al. Transient inhibition of ATM kinase is sufficient to inhance cellular sensitivity to ionizing radiation. Cancer Res. 2008, 68(18), 7466-7474.
- F Dumont et al. Radiosensitising agents for the radiotherapy of cancer: novel molecularly targeted approaches. Expert Opin. Ther. Pat. 2009, 19(6), 775-799.
- List of publications using CP 466722 (Axon 1495) purchased from Axon Medchem
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