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INK 128
- MLN0128 - Sapanisertib
- Soluble in 0.1N HCl(aq) and DMSO
- MF: C15H15N7O
- MW: 309.33
Description
Potent and selective mTOR inhibitor.
More Information
| Parent CAS No. | 1224844-38-5 |
|---|---|
| Chemical Name | 5-(4-amino-1-isopropyl-1H-pyrazolo[3,4-d]pyrimidin-3-yl)benzo[d]oxazol-2-amine |
| SMILES | C1=NC(N)=C2C(C3=CC=C4OC(N)=NC4=C3)=NN(C(C)C)C2=N1 |
| MFCD | MFCD22124893 |
| InChi | InChI=1S/C15H15N7O/c1-7(2)22-14-11(13(16)18-6-19-14)12(21-22)8-3-4-10-9(5-8)20-15(17)23-10/h3-7H,1-2H3,(H2,17,20)(H2,16,18,19) |
| InChiKey | GYLDXIAOMVERTK-UHFFFAOYSA-N |
| CID | 45375953 |
| Short Description | mTOR inhibitor |
References
- AC Hsieh, Y Liu et al. The translational landscape of mTOR signalling steers cancer initiation and metastasis. Nature 2012, 485, 55–61.
- K Jessen et al. Abstract B148: INK128 is a potent and selective TORC1/2 inhibitor with broad oral antitumor activity. Mol. Cancer Ther. 2009, 8(12), S1.
- MR Janes et al. Efficacy of the investigational mTOR kinase inhibitor MLN0128/INK128 in models of B-cell acute lymphoblastic leukemia. Leukemia. 2013, 27(3), 586-594.
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