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LX2343
- Soluble in DMSO
- MF: C22H19ClN2O6S
- MW: 474.91
Description
Inhibitor of human β-secretase (BACE-1) and PI3K (non-ATP competitive) with IC50 values of 11 µM and 16 µM, respectively. Moreover, LX2343 ameliorates cognitive dysfunction in APP/PS1 transgenic mice via both Aβ production inhibition and clearance promotion. Potentially effective in the treatment of Alzheimer's disease.
More Information
| Parent CAS No. | 333745-53-2 |
|---|---|
| Chemical Name | N-(Benzo[d][1,3]dioxol-5-yl)-2-(N-(5-chloro-2-methoxyphenyl)phenylsulfonamido)acetamide |
| SMILES | C1(Cl)C=C(N(CC(NC2C=CC3OCOC=3C=2)=O)S(=O)(=O)C2C=CC=CC=2)C(OC)=CC=1 |
| MFCD | N.A. |
| InChi | InChI=1S/C22H19ClN2O6S/c1-29-19-9-7-15(23)11-18(19)25(32(27,28)17-5-3-2-4-6-17)13-22(26)24-16-8-10-20-21(12-16)31-14-30-20/h2-12H,13-14H2,1H3,(H,24,26) |
| InChiKey | ZGYSGIYKAVUVOR-UHFFFAOYSA-N |
| CID | 1000980 |
| Short Description | BACE inhibitor |
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