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AZD8055
- Optical Purity: Optically pure
- Soluble in 0.1N HCl(aq) and DMSO
- MF: C25H31N5O4
- MW: 465.54
Description
AZD8055 is a potent, selective ATP-competitive mTOR kinase inhibitor with reported IC50 value of approximately 0.8 nM, exhibiting selectivity ca 1000-fold against class I PI3K and other PIKKs.
By directly inhibiting mTOR catalytic activity, AZD8055 suppresses both mTORC1 and mTORC2 signaling outputs. It is useful for dissecting mTOR-dependent protein synthesis, autophagy, metabolism and growth-control pathways in cancer and cell biology models.
Key Features
- Potent ATP-competitive mTOR kinase inhibitor
- Reported IC50 around 0.8 nM
- Inhibits signaling from both mTORC1 and mTORC2
- Highly selective over class I PI3K and related PIKKs
Applications
- mTOR pathway research
- PI3K/AKT/mTOR signaling assays
- Autophagy and protein synthesis studies
- Cancer cell growth and survival models
More Information
| Parent CAS No. | 1009298-09-2 |
|---|---|
| Chemical Name | (5-(2,4-bis((S)-3-methylmorpholino)pyrido[2,3-d]pyrimidin-7-yl)-2-methoxyphenyl)methanol |
| SMILES | C1C=C2C(N3CCOC[C@@H]3C)=NC(N3[C@@H](C)COCC3)=NC2=NC=1C1C=CC(OC)=C(CO)C=1 |&1:9,14,r| |
| MFCD | N.A. |
| InChi | InChI=1S/C25H31N5O4/c1-16-14-33-10-8-29(16)24-20-5-6-21(18-4-7-22(32-3)19(12-18)13-31)26-23(20)27-25(28-24)30-9-11-34-15-17(30)2/h4-7,12,16-17,31H,8-11,13-15H2,1-3H3/t16-,17-/m0/s1 |
| InChiKey | KVLFRAWTRWDEDF-IRXDYDNUSA-N |
| CID | 25262965 |
| Short Description | mTOR inhibitor |
References
- CM Chresta et al. AZD8055 Is a Potent, Selective, and Orally Bioavailable ATP-Competitive Mammalian Target of Rapamycin Kinase Inhibitor with In vitro and In vivo Antitumor Activity. Cancer Res. 2010, 70(1), 288-298.
- P Sini et al. Simultaneous inhibition of mTORC1 and mTORC2 by mTOR kinase inhibitor AZD8055 induces autophagy and cell death in cancer cells. Autophagy. 2010, 6(4).
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