CNS
The human nervous system is divided into the central nervous system (CNS) and the peripheral nervous system (PNS). The CNS, in turn, is divided into the brain and the spinal cord, which lie in the cranial cavity of the skull and the vertebral canal, respectively. The CNS and the PNS, acting in concert, integrate sensory information and control motor and cognitive functions. Based on its functions, the CNS can be divided into three main functional components: the sensory system, the motor system, and homeostatic and higher brain functions. Cell signaling throughout the CNS occurs by means of neurotransmitters or ions of various kinds interacting at membrane bound receptors and ion channels that, in turn, send the signal through second messenger systems to different compartments of the cell. Malfunctions of the CNS can cause numerous diseases and disorders such as Alzheimer's and Parkinson's disease, multiple sclerosis (MS), anxiety, schizophrenia, and many others. Although many of these failures of the CNS appear to be age related, some occur already in a very early stage of development of the organism, or may even be genetically inherited. The prevention and treatment of neurological disorders represents one of the most difficult and challenging goals of modern medical research.
Axon ID | Name | Description | From price | |
---|---|---|---|---|
2989 | 15-LOX-1 inhibitor i472 | Inhibitor of 15-lipoxygenase-1 (15-LOX-1) | €165.00 | |
2811 | 25CN-NBOH hydrochloride | Selective brain penetrant 5-HT2A receptor agonist | €145.00 | |
2694 | 4BP-TQS | Allosteric agonist of α7 nAChR | €105.00 | |
1575 | 5-HT6 antagonist 29 | Selective brain penetrant 5-HT6 receptor antagonist | €90.00 | |
1909 | A 1070722 | Selective inhibitor of GSK-3 | €95.00 | |
2944 | A 381393 | Potent, brain-penetrant, selective antagonist of the dopamine D4 receptor | €125.00 | |
1816 | A 784168 | TRPV1 receptor antagonist | €95.00 | |
1915 | A 803467 | Blocker of the voltage-gated Nav1.8 channel | €95.00 | |
2182 | A 804598 | Potent and selective P2X7 antagonist | €125.00 | |
2155 | A 841720 | Non-competitive mGluR1 antagonist | €85.00 | |
1990 | A 943931 | H4 antagonist | €70.00 | |
3019 | A2764 dihydrochloride | Selective inhibitor of the TRESK potassium channel | €105.00 | |
3060 | A2793 | Inhibitor of the TRESK and TASK-1 potassium channel | €95.00 | |
1504 | ABT 102 | TRPV1 antagonist | €90.00 | |
1510 | ABT 239 tartrate | H3 antagonist/inverse agonist | €120.00 |