CNS
The human nervous system is divided into the central nervous system (CNS) and the peripheral nervous system (PNS). The CNS, in turn, is divided into the brain and the spinal cord, which lie in the cranial cavity of the skull and the vertebral canal, respectively. The CNS and the PNS, acting in concert, integrate sensory information and control motor and cognitive functions. Based on its functions, the CNS can be divided into three main functional components: the sensory system, the motor system, and homeostatic and higher brain functions. Cell signaling throughout the CNS occurs by means of neurotransmitters or ions of various kinds interacting at membrane bound receptors and ion channels that, in turn, send the signal through second messenger systems to different compartments of the cell. Malfunctions of the CNS can cause numerous diseases and disorders such as Alzheimer's and Parkinson's disease, multiple sclerosis (MS), anxiety, schizophrenia, and many others. Although many of these failures of the CNS appear to be age related, some occur already in a very early stage of development of the organism, or may even be genetically inherited. The prevention and treatment of neurological disorders represents one of the most difficult and challenging goals of modern medical research.
Axon ID | Name | Description | From price | |
---|---|---|---|---|
2624 | BF844 | CLRN1-N48K stabilizer | €105.00 | |
3047 | BI-6C9 | Inhibitor of BID protein | €145.00 | |
3156 | Centhaquin | Centrally acting hypotensive agent | €90.00 | |
2915 | CID 1375606 | Analog of CID 5157334 | €95.00 | |
3926 | CID 5157334 | Selective surrogate agonist for GPR27 | €95.00 | |
1654 | CP 100356 hydrochloride | P-gp inhibitor | €90.00 | |
1896 | Elacridar hydrochloride | P-gp inhibitor (3rd generation ABCB1 modulator) | €80.00 | |
2080 | EVP 4593 | NF-κB activation inhibitor; inhibits SOC pathway | €110.00 | |
2962 | FTBMT | Potent, selective and orally available GPR52 agonist | €125.00 | |
3522 | GPR52 Comp-43 | Highly potent and specific GPR52 antagonist | €90.00 | |
2569 | JNJ 63533054 | Potent, brain-penetrant, selective agonist of GPR139 | €90.00 | |
2591 | MC70 hydrochloride | Potent P-gp inhibitor with good selectivity towards BCRP pump | €125.00 | |
2609 | NCRW0005-F05 | GPR139 antagonist; useful tool to study GPR139 pharmacology | €130.00 | |
3277 | NSC194598 | p53 DNA-binding inhibitor | €130.00 | |
3784 | PGP-4008 | Selective P-glycoprotein (Pgp) inhibitor | €120.00 | |
2627 | SMER 28 | Small molecule enhancer of rapamycin that enhances autophagy | €80.00 | |
3485 | Soticlestat | Potent, selective, orally active and brain-penetrant cholesterol 24-hydroxylase (CYP46A1) inhibitor | €80.00 | |
1960 | Tariquidar | Inhibitor of P-glycoprotein (P-gp, ABCB1) | €135.00 | |
1839 | Zosuquidar trihydrochloride | Inhibitor of P-glycoprotein | €95.00 |