CNS

The human nervous system is divided into the central nervous system (CNS) and the peripheral nervous system (PNS). The CNS, in turn, is divided into the brain and the spinal cord, which lie in the cranial cavity of the skull and the vertebral canal, respectively. The CNS and the PNS, acting in concert, integrate sensory information and control motor and cognitive functions. Based on its functions, the CNS can be divided into three main functional components: the sensory system, the motor system, and homeostatic and higher brain functions. Cell signaling throughout the CNS occurs by means of neurotransmitters or ions of various kinds interacting at membrane bound receptors and ion channels that, in turn, send the signal through second messenger systems to different compartments of the cell. Malfunctions of the CNS can cause numerous diseases and disorders such as Alzheimer's and Parkinson's disease, multiple sclerosis (MS), anxiety, schizophrenia, and many others. Although many of these failures of the CNS appear to be age related, some occur already in a very early stage of development of the organism, or may even be genetically inherited. The prevention and treatment of neurological disorders represents one of the most difficult and challenging goals of modern medical research.

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Axon ID Name Description From price
2624 BF844 CLRN1-N48K stabilizer €105.00
3047 BI-6C9 Inhibitor of BID protein  Recently added €145.00
2915 CID 1375606 Selective surrogate agonist for GPR27 €95.00
1654 CP 100356 hydrochloride P-gp inhibitor €125.00
1896 Elacridar hydrochloride P-gp inhibitor (3rd generation ABCB1 modulator) €80.00
2080 EVP 4593 NF-κB activation inhibitor; inhibits SOC pathway €110.00
2569 JNJ 63533054 Potent, brain-penetrant, selective agonist of GPR139 €90.00
1839 LY 335979 Inhibitor of P-glycoprotein €95.00
2591 MC70 hydrochloride Potent P-gp inhibitor with good selectivity towards BCRP pump €125.00
2609 NCRW0005-F05 GPR139 antagonist; useful tool to study GPR139 pharmacology €125.00
2627 SMER 28 Small molecule enhancer of rapamycin that enhances autophagy €80.00
1960 Tariquidar Inhibitor of P-glycoprotein (P-gp, ABCB1) €135.00

12 Item(s)

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