CNS

The human nervous system is divided into the central nervous system (CNS) and the peripheral nervous system (PNS). The CNS, in turn, is divided into the brain and the spinal cord, which lie in the cranial cavity of the skull and the vertebral canal, respectively. The CNS and the PNS, acting in concert, integrate sensory information and control motor and cognitive functions. Based on its functions, the CNS can be divided into three main functional components: the sensory system, the motor system, and homeostatic and higher brain functions. Cell signaling throughout the CNS occurs by means of neurotransmitters or ions of various kinds interacting at membrane bound receptors and ion channels that, in turn, send the signal through second messenger systems to different compartments of the cell. Malfunctions of the CNS can cause numerous diseases and disorders such as Alzheimer's and Parkinson's disease, multiple sclerosis (MS), anxiety, schizophrenia, and many others. Although many of these failures of the CNS appear to be age related, some occur already in a very early stage of development of the organism, or may even be genetically inherited. The prevention and treatment of neurological disorders represents one of the most difficult and challenging goals of modern medical research.

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Axon ID Name Description From price
2624 BF844 CLRN1-N48K stabilizer €105.00
3047 BI-6C9 Inhibitor of BID protein €145.00
3156 Centhaquin Centrally acting hypotensive agent €90.00
2915 CID 1375606 Analog of CID 5157334 €95.00
3926 CID 5157334 Selective surrogate agonist for GPR27 €95.00
1654 CP 100356 hydrochloride P-gp inhibitor €90.00
1896 Elacridar hydrochloride P-gp inhibitor (3rd generation ABCB1 modulator) €80.00
2080 EVP 4593 NF-κB activation inhibitor; inhibits SOC pathway €110.00
2962 FTBMT Potent, selective and orally available GPR52 agonist €125.00
3522 GPR52 Comp-43 Highly potent and specific GPR52 antagonist €90.00
2569 JNJ 63533054 Potent, brain-penetrant, selective agonist of GPR139 €90.00
2591 MC70 hydrochloride Potent P-gp inhibitor with good selectivity towards BCRP pump €125.00
2609 NCRW0005-F05 GPR139 antagonist; useful tool to study GPR139 pharmacology €130.00
3277 NSC194598 p53 DNA-binding inhibitor €130.00
3784 PGP-4008 Selective P-glycoprotein (Pgp) inhibitor €120.00
2627 SMER 28 Small molecule enhancer of rapamycin that enhances autophagy €80.00
3485 Soticlestat Potent, selective, orally active and brain-penetrant cholesterol 24-hydroxylase (CYP46A1) inhibitor €80.00
1960 Tariquidar Inhibitor of P-glycoprotein (P-gp, ABCB1) €135.00
1839 Zosuquidar trihydrochloride Inhibitor of P-glycoprotein €95.00

19 Item(s)

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