CNS

The human nervous system is divided into the central nervous system (CNS) and the peripheral nervous system (PNS). The CNS, in turn, is divided into the brain and the spinal cord, which lie in the cranial cavity of the skull and the vertebral canal, respectively. The CNS and the PNS, acting in concert, integrate sensory information and control motor and cognitive functions. Based on its functions, the CNS can be divided into three main functional components: the sensory system, the motor system, and homeostatic and higher brain functions. Cell signaling throughout the CNS occurs by means of neurotransmitters or ions of various kinds interacting at membrane bound receptors and ion channels that, in turn, send the signal through second messenger systems to different compartments of the cell. Malfunctions of the CNS can cause numerous diseases and disorders such as Alzheimer's and Parkinson's disease, multiple sclerosis (MS), anxiety, schizophrenia, and many others. Although many of these failures of the CNS appear to be age related, some occur already in a very early stage of development of the organism, or may even be genetically inherited. The prevention and treatment of neurological disorders represents one of the most difficult and challenging goals of modern medical research.

12 Item(s)

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Axon ID Name Description From price
2269 AK 1 Potent inhibitor of SIRT with good selectivity for SIRT2 over SIRT1 and SIRT3 €90.00
2270 AK 7 Potent, brain-permeable and selective inhibitor of SIRT2 €90.00
2306 Bizine Potent LSD1 inhibitor with selectivity over MAO-A/B, and LSD2 €120.00
2803 Cambinol Inhibitor of SIRT1 and SIRT2 €95.00
2195 RGFP 966 HDAC3 specific inhibitor €85.00
2245 RVX 208 BET bromodomain inhibitor specific for second bromodomains (BD2s) €65.00
2704 Salermide Potent inhibitor of SIRT1 and SIRT2 €95.00
1956 Selisistat Potent and selective SIRT1 inhibitor €90.00
2453 SirReal 2 SIRT2 inhibitor with >1000 fold selectivity over SIRT1 and SIRT3 €95.00
1875 SRT 1720 tetrahydrochloride Activator of the sirtuin subtype SIRT1 €135.00
2008 Tenovin 1 Activates p53 through inhibition of SIRT 1 and 2 €70.00
2249 Tenovin 6 Small water soluble p53 activator and SIRT inhibitor €105.00

12 Item(s)

per page
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