CNS

The human nervous system is divided into the central nervous system (CNS) and the peripheral nervous system (PNS). The CNS, in turn, is divided into the brain and the spinal cord, which lie in the cranial cavity of the skull and the vertebral canal, respectively. The CNS and the PNS, acting in concert, integrate sensory information and control motor and cognitive functions. Based on its functions, the CNS can be divided into three main functional components: the sensory system, the motor system, and homeostatic and higher brain functions. Cell signaling throughout the CNS occurs by means of neurotransmitters or ions of various kinds interacting at membrane bound receptors and ion channels that, in turn, send the signal through second messenger systems to different compartments of the cell. Malfunctions of the CNS can cause numerous diseases and disorders such as Alzheimer's and Parkinson's disease, multiple sclerosis (MS), anxiety, schizophrenia, and many others. Although many of these failures of the CNS appear to be age related, some occur already in a very early stage of development of the organism, or may even be genetically inherited. The prevention and treatment of neurological disorders represents one of the most difficult and challenging goals of modern medical research.

11 Item(s)

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Axon ID Name Description From price
1816 A 784168 TRPV1 receptor antagonist €95.00
2182 A 804598 Potent and selective P2X7 antagonist €125.00
1504 ABT 102 TRPV1 antagonist €90.00
2523 BX 430 Allosteric antagonist of human P2X4 receptor channels €105.00
2742 GSK 2193874 Orally active TRPV4 antagonist €120.00
1967 GW 791343 hydrochloride P2X7 receptor antagonist and allosteric modulator Inquire
2890 JNJ 47965567 Potent, brain-penetrant P2X7 antagonist €135.00
2423 M8-B hydrochloride Selective and potent antagonist of the TRPM8 channel €115.00
2374 Optovin Reversible photoactivated TRPA1 agonist €85.00
2483 PF 05105679 TRPM8 inhibitor with >100-fold selectivity and in vivo activity in humans €90.00
2498 RQ 00203078 Selective, potent, and orally active TRPM8 antagonist with in vivo activity €125.00

11 Item(s)

per page
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