CNS
The human nervous system is divided into the central nervous system (CNS) and the peripheral nervous system (PNS). The CNS, in turn, is divided into the brain and the spinal cord, which lie in the cranial cavity of the skull and the vertebral canal, respectively. The CNS and the PNS, acting in concert, integrate sensory information and control motor and cognitive functions. Based on its functions, the CNS can be divided into three main functional components: the sensory system, the motor system, and homeostatic and higher brain functions. Cell signaling throughout the CNS occurs by means of neurotransmitters or ions of various kinds interacting at membrane bound receptors and ion channels that, in turn, send the signal through second messenger systems to different compartments of the cell. Malfunctions of the CNS can cause numerous diseases and disorders such as Alzheimer's and Parkinson's disease, multiple sclerosis (MS), anxiety, schizophrenia, and many others. Although many of these failures of the CNS appear to be age related, some occur already in a very early stage of development of the organism, or may even be genetically inherited. The prevention and treatment of neurological disorders represents one of the most difficult and challenging goals of modern medical research.
Axon ID | Name | Description | From price | |
---|---|---|---|---|
4114 | (±)-trans-ML-SI3 | TRPML1/3 inhibitor and TRPML2 activator | Recently added | €120.00 |
1816 | A 784168 | TRPV1 receptor antagonist | €95.00 | |
2182 | A 804598 | Potent and selective P2X7 antagonist | €125.00 | |
3835 | A-438079 hydrochloride | Competitive P2X7 antagonist | €110.00 | |
1504 | ABT 102 | TRPV1 antagonist | €90.00 | |
3356 | AMG 9810 | Potent and selective vanilloid receptor-1 (TRPV1) antagonist | €90.00 | |
2523 | BX 430 | Allosteric antagonist of human P2X4 receptor channels | €105.00 | |
2742 | GSK 2193874 | Orally active TRPV4 antagonist | €120.00 | |
1967 | GW 791343 hydrochloride | P2X7 receptor antagonist and allosteric modulator | Inquire | |
2890 | JNJ 47965567 | Potent, brain-penetrant P2X7 antagonist | €130.00 | |
2423 | M8-B hydrochloride | Selective and potent antagonist of the TRPM8 channel | €115.00 | |
2374 | Optovin | Reversible photoactivated TRPA1 agonist | €85.00 | |
2483 | PF 05105679 | TRPM8 inhibitor with >100-fold selectivity and in vivo activity in humans | €95.00 | |
2498 | RQ 00203078 | Selective, potent, and orally active TRPM8 antagonist with in vivo activity | €125.00 |