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(+)-Pagoclone - CI 1043

Based on 20 reference(s) in Google Scholar 80 100 20

Axon 1594

CAS [133737-32-3]

MF C23H22ClN3O2
MW 407.89

  • Purity: 99%
  • Optical purity: Optically pure
  • Soluble in DMSO

(+)-Pagoclone

Description

Subtype selective partial agonist at GABAA receptor, which binds primarily to the α2/α3 subtypes which are responsible for the anti-anxiety effects of these kind of drugs, but has relatively little efficacy at the α1 subtype which produces the sedative and memory loss effects; nonbenzodiazepine anxiolytic
JR Atack. The benzodiazepine binding site of GABA(A) receptors as a target for the development of novel anxiolytics. Exp. Opin. Invest. Drugs. 2005, 14(5), 601-618.
 
DJ Nutt. Alcohol alternatives - a goal for psychopharmacology? J. Psychopharmacol. 2006, 20(3), 318–320. 
GABAA-α2 and GABAA-α3 agonist

Chemical name

2-(7-chloro-1,8-naphthyridin-2-yl)-3-(5-methyl-2-oxohexyl)isoindolin-1-one

Parent CAS No.

[133737-32-3]

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5 mg €135.00 In Stock
25 mg €475.00 In Stock
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The purity of Axon Ligands™ is confirmed by HPLC-MS, 1H-NMR and/or microanalysis. Analytical data are available upon request.

Caution: Axon Ligands™ are not fully tested. They are for research purposes only! Not for human consumption!

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