CNS
The human nervous system is divided into the central nervous system (CNS) and the peripheral nervous system (PNS). The CNS, in turn, is divided into the brain and the spinal cord, which lie in the cranial cavity of the skull and the vertebral canal, respectively. The CNS and the PNS, acting in concert, integrate sensory information and control motor and cognitive functions. Based on its functions, the CNS can be divided into three main functional components: the sensory system, the motor system, and homeostatic and higher brain functions. Cell signaling throughout the CNS occurs by means of neurotransmitters or ions of various kinds interacting at membrane bound receptors and ion channels that, in turn, send the signal through second messenger systems to different compartments of the cell. Malfunctions of the CNS can cause numerous diseases and disorders such as Alzheimer's and Parkinson's disease, multiple sclerosis (MS), anxiety, schizophrenia, and many others. Although many of these failures of the CNS appear to be age related, some occur already in a very early stage of development of the organism, or may even be genetically inherited. The prevention and treatment of neurological disorders represents one of the most difficult and challenging goals of modern medical research.
Axon ID | Name | Description | From price | |
---|---|---|---|---|
1077 | (+)-Epibatidine dihydrochloride | Nicotinic acetylcholine receptor agonist | €155.00 | |
1078 | (-)-Epibatidine dihydrochloride | Nicotinic acetylcholine receptor agonist | €155.00 | |
1076 | (±)-Epibatidine dihydrochloride | Nicotinic acetylcholine receptor agonist | €95.00 | |
2694 | 4BP-TQS | Allosteric agonist of α7 nAChR | €110.00 | |
2401 | AT 1001 | High affinity and selective α3β4 nAChR ligand with partial agonistic and antagonistic effects | €95.00 | |
2796 | Clozapine N-oxide | Muscarinic DREADD agonist | €85.00 | |
3478 | Dehydroevodiamine hydrochloride | Potent acetylcholinesterase inhibitor | €70.00 | |
1438 | Donepezil hydrochloride | Acetylcholinesterase inhibitor | €60.00 | |
2621 | GAT107 | allosteric agonist and PAM of α7 nAChR | €110.00 | |
3707 | GLN-1062 | Brain-pentrant prodrug of galantamine; Acetylcholinesterase inhibitor | €120.00 | |
1289 | GMC 1-109 | Clozapine analog devoid of DA, 5-HT2, H1 and α1 affinities, but with high M1 affinity | €125.00 | |
2860 | GTS 21 dihydrochloride | Selective α7 nicotinic acetylcholine receptor (nAChR) partial agonist | €90.00 | |
3280 | JHU37152 | Potent and CNS-active DREADD agonist | €90.00 | |
3281 | JHU37160 | Potent and CNS-active DREADD agonist | €90.00 | |
1679 | MDL 201012 | Muscarinic M3 antagonist | €110.00 | |
3658 | Neostigmine methyl sulfate | Reversible acetylcholinesterase inhibitor | €40.00 | |
3505 | Oxybutynin hydrochloride | Competitive M1/M2/M3 mAChR antagonist | €50.00 | |
3286 | Penehyclidine hydrochloride | Anticholinergic drug | €130.00 | |
2109 | PHA 543613 dihydrochloride | nAChR agonist (α7 sub-unit selective) | €115.00 | |
2908 | PNU 282987 hydrochloride | nAChR agonist (α7 sub-unit selective) | €90.00 | |
3151 | QND7 | nAChR antagonist (α7 sub-unit selective) | €130.00 | |
3167 | Rivastigmine tartrate | Centrally selective acetylcholinesterase inhibitor | €60.00 | |
2463 | TBPB | Allosteric activator of the M1 acetylcholine receptor devoid of M2-M5 activity. | €105.00 | |
2049 | Tolterodine L-tartrate | Muscarinic receptor (mAChR) antagonist | €60.00 | |
1384 | Varenicline dihydrochloride | Nicotinic acetylcholine receptor agonist | €80.00 | |
2074 | Varenicline tartrate | Selective α4β2 nicotinic acetylcholine receptor (nAChR) partial agonist | €80.00 | |
1988 | VU 0029767 | PAM of mAChR M1 that potentiates the agonistic effect of Ach | €110.00 | |
1483 | VU 0152100 | PAM of M4 mAChR | €85.00 | |
1786 | VU 0238429 | Selective PAM of M5 mAChR (CHRM5) | €105.00 | |
1787 | VU 0255035 | Selective M1 mAChR Antagonist | €120.00 |