CNS

The human nervous system is divided into the central nervous system (CNS) and the peripheral nervous system (PNS). The CNS, in turn, is divided into the brain and the spinal cord, which lie in the cranial cavity of the skull and the vertebral canal, respectively. The CNS and the PNS, acting in concert, integrate sensory information and control motor and cognitive functions. Based on its functions, the CNS can be divided into three main functional components: the sensory system, the motor system, and homeostatic and higher brain functions. Cell signaling throughout the CNS occurs by means of neurotransmitters or ions of various kinds interacting at membrane bound receptors and ion channels that, in turn, send the signal through second messenger systems to different compartments of the cell. Malfunctions of the CNS can cause numerous diseases and disorders such as Alzheimer's and Parkinson's disease, multiple sclerosis (MS), anxiety, schizophrenia, and many others. Although many of these failures of the CNS appear to be age related, some occur already in a very early stage of development of the organism, or may even be genetically inherited. The prevention and treatment of neurological disorders represents one of the most difficult and challenging goals of modern medical research.

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Axon ID Name Description From price
2694 4BP-TQS Allosteric agonist of α7 nAChR €105.00
2401 AT 1001 High affinity and selective α3β4 nAChR ligand with partial agonistic and antagonistic effects €95.00
2796 Clozapine N-oxide Muscarinic DREADD agonist €85.00
1438 Donepezil hydrochloride Acetylcholinesterase inhibitor €75.00
1077 Epibatidine dihydrochloride, (+)- Nicotinic acetylcholine receptor agonist €155.00
1078 Epibatidine dihydrochloride, (-)- Nicotinic acetylcholine receptor agonist €155.00
1076 Epibatidine dihydrochloride, (±)- Nicotinic acetylcholine receptor agonist €95.00
2621 GAT107 allosteric agonist and PAM of α7 nAChR €105.00
1289 GMC 1-109 Clozapine analog devoid of DA, 5-HT2, H1 and α1 affinities, but with high M1 affinity €125.00
2860 GTS 21 dihydrochloride Selective α7 nicotinic acetylcholine receptor (nAChR) partial agonist €90.00
1679 MDL 201012 Muscarinic M3 antagonist €110.00
2109 PHA 543613 dihydrochloride nAChR agonist (α7 sub-unit selective) €115.00
2908 PNU 282987 hydrochloride nAChR agonist (α7 sub-unit selective) €90.00
2463 TBPB Allosteric activator of the M1 acetylcholine receptor devoid of M2-M5 activity. €105.00
2049 Tolterodine L-tartrate Muscarinic receptor (mAChR) antagonist €90.00

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