CNS
The human nervous system is divided into the central nervous system (CNS) and the peripheral nervous system (PNS). The CNS, in turn, is divided into the brain and the spinal cord, which lie in the cranial cavity of the skull and the vertebral canal, respectively. The CNS and the PNS, acting in concert, integrate sensory information and control motor and cognitive functions. Based on its functions, the CNS can be divided into three main functional components: the sensory system, the motor system, and homeostatic and higher brain functions. Cell signaling throughout the CNS occurs by means of neurotransmitters or ions of various kinds interacting at membrane bound receptors and ion channels that, in turn, send the signal through second messenger systems to different compartments of the cell. Malfunctions of the CNS can cause numerous diseases and disorders such as Alzheimer's and Parkinson's disease, multiple sclerosis (MS), anxiety, schizophrenia, and many others. Although many of these failures of the CNS appear to be age related, some occur already in a very early stage of development of the organism, or may even be genetically inherited. The prevention and treatment of neurological disorders represents one of the most difficult and challenging goals of modern medical research.
Axon ID | Name | Description | From price | |
---|---|---|---|---|
1594 | (+)-Pagoclone | GABAA-α2 and GABAA-α3 agonist | €135.00 | |
2784 | (R)-(-)-N-Desmethyl-PK 11195 | Radioligand precursor of the benzodiazepine antagonist (R)-(-)-PK 11195 | €150.00 | |
2785 | (R)-(-)-PK 11195 | Benzodiazepine antagonist. | €130.00 | |
3698 | AC-5216 | Selective translocator protein (TSPO) ligand | €90.00 | |
3042 | AZD6280 | Selective, orally active, allosteric GABA-A α2/3 receptor modulator | €125.00 | |
3087 | AZD7325 | Potent, selective GABAA-α2 and GABAA-α3 modulator | €90.00 | |
1604 | CP 615003 mesylate | GABAA agonist | €90.00 | |
3406 | Demoxepam | Metabolite of Chlordiazepoxide | €120.00 | |
3388 | Etifoxine | PAM of GABAA | €90.00 | |
3331 | Etifoxine hydrochloride | PAM of GABAA | €110.00 | |
1301 | Gabapentin | GABA modulator; Anti-convulsant | €65.00 | |
1820 | GS 39783 | PAM of GABA-B Receptor | €90.00 | |
1196 | L 838417 | GABAA-α1 antagonist | €90.00 | |
3390 | L-655,708 | Selective inverse agonist of GABAA-α5 | €120.00 | |
2833 | N-Desmethyl-PK 11195 | Radioligand precursor of the benzodiazepine antagonist PK 11195 | €105.00 | |
1121 | NBI 34060 | PAM of GABAA-α1 | €95.00 | |
1457 | NS 11394 | PAM of GABAA | €110.00 | |
1208 | PK 11195 | Benzodiazepine antagonist | €65.00 | |
1195 | SL 651498 | GABAA-α2 agonist | €80.00 | |
3119 | Stiripentol | PAM of GABAA | €70.00 | |
1422 | TP003 | GABAA-α3 agonist | €80.00 | |
1646 | Zaleplon | GABAA-α1 agonist | €70.00 | |
1197 | Zopiclone | Benzodiazepine agonist | €70.00 |