CNS
The human nervous system is divided into the central nervous system (CNS) and the peripheral nervous system (PNS). The CNS, in turn, is divided into the brain and the spinal cord, which lie in the cranial cavity of the skull and the vertebral canal, respectively. The CNS and the PNS, acting in concert, integrate sensory information and control motor and cognitive functions. Based on its functions, the CNS can be divided into three main functional components: the sensory system, the motor system, and homeostatic and higher brain functions. Cell signaling throughout the CNS occurs by means of neurotransmitters or ions of various kinds interacting at membrane bound receptors and ion channels that, in turn, send the signal through second messenger systems to different compartments of the cell. Malfunctions of the CNS can cause numerous diseases and disorders such as Alzheimer's and Parkinson's disease, multiple sclerosis (MS), anxiety, schizophrenia, and many others. Although many of these failures of the CNS appear to be age related, some occur already in a very early stage of development of the organism, or may even be genetically inherited. The prevention and treatment of neurological disorders represents one of the most difficult and challenging goals of modern medical research.
Axon ID | Name | Description | From price | |
---|---|---|---|---|
1309 | (R)-(-)-BMS 204352 | Potassium channel opener; Less active enantiomer of Axon 1112 | €145.00 | |
1308 | (±)-BMS 204352 | Potassium channel opener; racemate of Axon 1112 | Inquire | |
1313 | 1-EBIO | K+ channel opener (Ca2+ activated) | €50.00 | |
3019 | A2764 dihydrochloride | Selective inhibitor of the TRESK potassium channel | €105.00 | |
3060 | A2793 | Inhibitor of the TRESK and TASK-1 potassium channel | €95.00 | |
2979 | ASP 2905 | Potent, selective and orally active KCNH3 (Kv12.2) inhibitor | €125.00 | |
2243 | AVE 0118 hydrochloride | Potassium channel blocker (Kv1.5 (IKur), Kv4.3 (Ito), Kir3.4 (IKAch), and IKr currents) | €120.00 | |
1112 | BMS 204352 | Maxi K+ channel opener | €120.00 | |
4122 | C101248 | First potent and selective THIK-1 inhibitor | €120.00 | |
1294 | Chromanol 293B | KCNQ1 channel blocker | €120.00 | |
1322 | DMP 543 | K+ channel blocker; Ach release stimulator | €90.00 | |
2103 | Dofetilide | Kv11.1 (hERG) channel blocker | €85.00 | |
4173 | Ebio1 | Potent and highly selective KCNQ2 activator | Recently added | €130.00 |
1437 | Flupirtine maleate | Analgesic | €65.00 | |
2064 | Glibenclamide potassium salt | KATP channel blocker; inhibits SUR1 | €50.00 | |
1757 | HMR 1098 | K+ channel blocker (SUR1/Kir6.2 selective) | €95.00 | |
2724 | ICA-069673 | KCNQ2/KCNQ3 channel opener; Anti-convulsant | €90.00 | |
3091 | ICA-110381 | KCNQ2/KCNQ3 channel opener; Anti-convulsant | €80.00 | |
1734 | K+ Channel inhibitor 1734 | Building Block for synthesis of Kv1.5 (IKur) inhibitors | €65.00 | |
3516 | KCa modulator RA-2 | Potent and selective KCa2/3 pan inhibitor | €110.00 | |
1735 | Kv1.3 Channel blocker 42 | Kv1.3 potassium channel blocker | €110.00 | |
2747 | ML 213 | KCNQ2/KCNQ4 channel opener | €75.00 | |
2436 | ML 297 | First potent and selective activator of the GIRK potassium channel | €95.00 | |
2872 | ML 335 | Selective activator of the TREK-1 and TREK-2 potassium channel | €110.00 | |
2840 | ML 365 | Potent and selective inhibitor of the TASK-1 potassium channel | €135.00 | |
2615 | ML252 | Selective and brain penetrant KCNQ2 inhibitor | €95.00 | |
1647 | NN 414 | K+ channel opener (SUR1/Kir6.2 selective) | €110.00 | |
2854 | NS 1619 | Selective activator of large-conductance Ca2+-activated potassium (BK) channels | €95.00 | |
2329 | NS 19504 | Potent activator of large-conductance Ca2+-activated potassium (BK) channels | €90.00 | |
2094 | NS 6180 | KCa3.1 channel blocker | €90.00 |