CNS

The human nervous system is divided into the central nervous system (CNS) and the peripheral nervous system (PNS). The CNS, in turn, is divided into the brain and the spinal cord, which lie in the cranial cavity of the skull and the vertebral canal, respectively. The CNS and the PNS, acting in concert, integrate sensory information and control motor and cognitive functions. Based on its functions, the CNS can be divided into three main functional components: the sensory system, the motor system, and homeostatic and higher brain functions. Cell signaling throughout the CNS occurs by means of neurotransmitters or ions of various kinds interacting at membrane bound receptors and ion channels that, in turn, send the signal through second messenger systems to different compartments of the cell. Malfunctions of the CNS can cause numerous diseases and disorders such as Alzheimer's and Parkinson's disease, multiple sclerosis (MS), anxiety, schizophrenia, and many others. Although many of these failures of the CNS appear to be age related, some occur already in a very early stage of development of the organism, or may even be genetically inherited. The prevention and treatment of neurological disorders represents one of the most difficult and challenging goals of modern medical research.

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Axon ID Name Description From price
1309 (R)-(-)-BMS 204352 Potassium channel opener; Less active enantiomer of Axon 1112 €145.00
1308 (±)-BMS 204352 Potassium channel opener; racemate of Axon 1112 Inquire
1313 1-EBIO K+ channel opener (Ca2+ activated) €50.00
3019 A2764 dihydrochloride Selective inhibitor of the TRESK potassium channel €105.00
3060 A2793 Inhibitor of the TRESK and TASK-1 potassium channel €95.00
2979 ASP 2905 Potent, selective and orally active KCNH3 (Kv12.2) inhibitor €125.00
2243 AVE 0118 hydrochloride Potassium channel blocker (Kv1.5 (IKur), Kv4.3 (Ito), Kir3.4 (IKAch), and IKr currents) €120.00
1112 BMS 204352 Maxi K+ channel opener €110.00
1294 Chromanol 293B KCNQ1 channel blocker €95.00
1322 DMP 543 K+ channel blocker; Ach release stimulator €90.00
2103 Dofetilide Kv11.1 (hERG) channel blocker €85.00
1437 Flupirtine maleate Analgesic €65.00
2064 Glibenclamide potassium salt KATP channel blocker; inhibits SUR1 €50.00
1757 HMR 1098 K+ channel blocker (SUR1/Kir6.2 selective) €95.00
2724 ICA-069673 KCNQ2/KCNQ3 channel opener; Anti-convulsant €90.00
3091 ICA-110381 KCNQ2/KCNQ3 channel opener; Anti-convulsant €80.00
1734 K+ Channel inhibitor 1734 Building Block for synthesis of Kv1.5 (IKur) inhibitors €65.00
3516 KCa modulator RA-2 Potent and selective KCa2/3 pan inhibitor €110.00
1735 Kv1.3 Channel blocker 42 Kv1.3 potassium channel blocker €110.00
2747 ML 213 KCNQ2/KCNQ4 channel opener €75.00
2436 ML 297 First potent and selective activator of the GIRK potassium channel €95.00
2872 ML 335 Selective activator of the TREK-1 and TREK-2 potassium channel €115.00
2840 ML 365 Potent and selective inhibitor of the TASK-1 potassium channel €135.00
2615 ML252 Selective and brain penetrant KCNQ2 inhibitor €95.00
1647 NN 414 K+ channel opener (SUR1/Kir6.2 selective) €110.00
2854 NS 1619 Selective activator of large-conductance Ca2+-activated potassium (BK) channels €95.00
2329 NS 19504 Potent activator of large-conductance Ca2+-activated potassium (BK) channels €90.00
2094 NS 6180 KCa3.1 channel blocker €90.00
2403 PK-THPP Potent TASK-3 antagonist with selectivity over a wide range of potassium channels €140.00
1525 Retigabine KCNQ channel opener; Anti-convulsant €90.00

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