CNS
The human nervous system is divided into the central nervous system (CNS) and the peripheral nervous system (PNS). The CNS, in turn, is divided into the brain and the spinal cord, which lie in the cranial cavity of the skull and the vertebral canal, respectively. The CNS and the PNS, acting in concert, integrate sensory information and control motor and cognitive functions. Based on its functions, the CNS can be divided into three main functional components: the sensory system, the motor system, and homeostatic and higher brain functions. Cell signaling throughout the CNS occurs by means of neurotransmitters or ions of various kinds interacting at membrane bound receptors and ion channels that, in turn, send the signal through second messenger systems to different compartments of the cell. Malfunctions of the CNS can cause numerous diseases and disorders such as Alzheimer's and Parkinson's disease, multiple sclerosis (MS), anxiety, schizophrenia, and many others. Although many of these failures of the CNS appear to be age related, some occur already in a very early stage of development of the organism, or may even be genetically inherited. The prevention and treatment of neurological disorders represents one of the most difficult and challenging goals of modern medical research.
Axon ID | Name | Description | From price | |
---|---|---|---|---|
3777 | (R)-AS-1 | First-in-class highly selective and orally bioavailable PAM of EAAT2 | €145.00 | |
1739 | (RS)-3,5-DHPG | mGluR1 and mGluR5 agonist (rac. Axon 1740) | €90.00 | |
1740 | (S)-3,5-DHPG | mGluR1 and mGluR5 agonist | €90.00 | |
1224 | (±)-LY 367385 | mGluR1a antagonist | €80.00 | |
3088 | 1-BCP | Brain-penetrant modulator of AMPA receptor | €75.00 | |
2155 | A 841720 | Non-competitive mGluR1 antagonist | €85.00 | |
2732 | ADX71743 | Negative allosteric modulator (NAM) of mGluR7 | €110.00 | |
3415 | AMPA | Highly selective AMPA receptor agonist | €110.00 | |
1747 | AZ 12216052 | Positive allosteric modulator (PAM) of mGluR8 | €110.00 | |
3335 | AZD6765 dihydrochloride | Noncompetitive NMDA antagonist | €90.00 | |
1644 | Biphenyl-indanone A | Positive allosteric modulator (PAM) of mGluR2 | €95.00 | |
1217 | CFM 2 | AMPA antagonist | €115.00 | |
2691 | CHPG | mGluR5 agonist | €95.00 | |
3333 | Cinnabarinic acid | mGluR4 agonist | €90.00 | |
4169 | CIQ | First NMDA NR2C/NR2D PAM | €130.00 | |
2079 | CMPDA | Positive allosteric modulator of AMPA receptor | €85.00 | |
1200 | CNQX | AMPA/Kainate antagonist | €85.00 | |
2522 | CNQX disodium salt | AMPA/Kainate antagonist | €90.00 | |
2254 | CP 101606 | NMDA NR2B antagonist | €120.00 | |
1406 | CP 101606 mesylate | NMDA NR2B antagonist | €85.00 | |
1431 | CPPHA | Positive allosteric modulator (PAM) of mGluR5 | €95.00 | |
1972 | CTEP | Negative allosteric modulator (NAM) of mGluR5 | €120.00 | |
3089 | CX516 | Positive allosteric modulator of AMPA receptor | €70.00 | |
3090 | CX546 | Positive allosteric modulator of AMPA receptor | €95.00 | |
1259 | Desmethyl YM 298198 hydrochloride | mGluR1 antagonist | €140.00 | |
3841 | Dextromethorphan hydrobromide | Noncompetitive NMDA receptor antagonist | €60.00 | |
1201 | DNQX | AMPA/Kainate antagonist | €50.00 | |
1246 | Eliprodil | NMDA antagonist | €90.00 | |
2687 | Farampator | Second-generation ampakine that potentiates AMPA receptor function | €99.00 | |
1345 | Fenobam | mGluR5 antagonist | €70.00 |