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(-)-Epibatidine dihydrochloride
- Parent CAS: 152378-30-8
- Optical Purity: 98% e.e.
- Soluble in water and DMSO
- MF: C11H13ClN2.2HCl
- MW: 281.61
Description
(-)-Epibatidine dihydrochloride is the (-)-enantiomer of epibatidine (Axon 1076) and a highly potent nicotinic acetylcholine receptor agonist. It can be used alongside (+)-epibatidine (Axon 1077) and the racemate for stereochemical analysis of nAChR activity.
Nicotinic receptor agonists are key tools for studying cholinergic transmission and pain-related signaling. (-)-Epibatidine dihydrochloride supports receptor subtype and enantiomer-dependence studies in nicotinic pharmacology.
Key Features
- Highly potent nicotinic acetylcholine receptor agonist
- (-)-enantiomer of racemic epibatidine
- Useful for enantiomer-dependent nAChR profiling
- Activates nicotinic acetylcholine receptor ion-channel signaling
Applications
- Nicotinic receptor pharmacology
- Cholinergic signaling assays
- Analgesia pathway research
- Stereoselective ligand comparison
More Information
| Parent CAS No. | 152378-30-8 |
|---|---|
| Chemical Name | (S)-2-(6-Chloro-pyridin-3-yl)-7-aza-bicyclo[2.2.1]heptane dihydrochloride |
| SMILES | C1C2[C@@](C3C=CC(Cl)=NC=3)([H])CC(N2)C1.Cl.Cl |&1:2,r| |
| MFCD | N.A. |
| InChi | InChI=1S/C11H13ClN2.2ClH/c12-11-4-1-7(6-13-11)9-5-8-2-3-10(9)14-8;;/h1,4,6,8-10,14H,2-3,5H2;2*1H/t8?,9-,10?;;/m0../s1 |
| InChiKey | DGNNWUINALNROG-SXOKBOPCSA-N |
| CID | 91826449 |
| Short Description | Nicotinic agonist |
References
- F Lembeck. Epibatidine: high potency and broad spectrum activity on neuronal and neuromuscular nicotinic acetylcholine receptors. Naunyn Schmiedebergs Arch. Pharmacol. 1999, 359, 378-385.
- MW Decker and MD Meyer. Therapeutic potential of neuronal nicotinic acetylcholine receptor agonists as novel analgesics. Biochem. Pharmacol. 1999, 58, 917-923.
- B. Badio et al. Epibatidine, a potent analgetic and nicotinic agonist. Mol. Pharmacol. 1994, 45, 563-569.
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