CNS

The human nervous system is divided into the central nervous system (CNS) and the peripheral nervous system (PNS). The CNS, in turn, is divided into the brain and the spinal cord, which lie in the cranial cavity of the skull and the vertebral canal, respectively. The CNS and the PNS, acting in concert, integrate sensory information and control motor and cognitive functions. Based on its functions, the CNS can be divided into three main functional components: the sensory system, the motor system, and homeostatic and higher brain functions. Cell signaling throughout the CNS occurs by means of neurotransmitters or ions of various kinds interacting at membrane bound receptors and ion channels that, in turn, send the signal through second messenger systems to different compartments of the cell. Malfunctions of the CNS can cause numerous diseases and disorders such as Alzheimer's and Parkinson's disease, multiple sclerosis (MS), anxiety, schizophrenia, and many others. Although many of these failures of the CNS appear to be age related, some occur already in a very early stage of development of the organism, or may even be genetically inherited. The prevention and treatment of neurological disorders represents one of the most difficult and challenging goals of modern medical research.

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Axon ID Name Description From price
1575 5-HT6 antagonist 29 Selective brain penetrant 5-HT6 receptor antagonist €90.00
2944 A 381393 Potent, brain-penetrant, selective antagonist of the dopamine D4 receptor  Recently added €125.00
1816 A 784168 TRPV1 receptor antagonist €95.00
2182 A 804598 Potent and selective P2X7 antagonist €125.00
2155 A 841720 Non-competitive mGluR1 antagonist €85.00
1990 A 943931 H4 antagonist €75.00
1504 ABT 102 TRPV1 antagonist €90.00
1510 ABT 239 tartrate H3 antagonist/inverse agonist €135.00
1097 Alosetron hydrochloride 5-HT3 antagonist €85.00
1218 AM 251 CB1 antagonist €95.00
1219 AM 281 CB1 antagonist €95.00
2791 AM 4113 CB1 antagonist €105.00
1648 Ambrisentan Endothelin-A (ETA) antagonist €75.00
1381 Amisulpride D2 and D3 antagonist €45.00
2468 ANA 12 Selective TrkB antagonist with anxiolytic and antidepressant activity in mice €90.00

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