CNS
The human nervous system is divided into the central nervous system (CNS) and the peripheral nervous system (PNS). The CNS, in turn, is divided into the brain and the spinal cord, which lie in the cranial cavity of the skull and the vertebral canal, respectively. The CNS and the PNS, acting in concert, integrate sensory information and control motor and cognitive functions. Based on its functions, the CNS can be divided into three main functional components: the sensory system, the motor system, and homeostatic and higher brain functions. Cell signaling throughout the CNS occurs by means of neurotransmitters or ions of various kinds interacting at membrane bound receptors and ion channels that, in turn, send the signal through second messenger systems to different compartments of the cell. Malfunctions of the CNS can cause numerous diseases and disorders such as Alzheimer's and Parkinson's disease, multiple sclerosis (MS), anxiety, schizophrenia, and many others. Although many of these failures of the CNS appear to be age related, some occur already in a very early stage of development of the organism, or may even be genetically inherited. The prevention and treatment of neurological disorders represents one of the most difficult and challenging goals of modern medical research.
Axon ID | Name | Description | From price | |
---|---|---|---|---|
1909 | A 1070722 | Selective inhibitor of GSK-3 | €95.00 | |
2167 | AR-A 014418 | ATP-competitive GSK-3 inhibitor | €85.00 | |
5053 | Axon Ligands™ Stem cell compound library | Axon Ligands™ Stem cell compound library | Inquire | |
2669 | AZ13705339 | Potent and selective PAK1 inhibitor | €125.00 | |
2171 | AZD1080 | Selective inhibitor of GSK-3α and GSK-3β | €90.00 | |
2194 | AZD2858 hydrochloride | Potent and highly selective Glycogen Synthase Kinase-3β inhibitor | €95.00 | |
1693 | BIO | GSK-3 inhibitor | €90.00 | |
2931 | BRD0705 | First-in-class, paralog selective GSK3α inhibitor | €210.00 | |
3153 | BRD5648 | Negative control compound of BRD0705 as a GSK3α inhibitor | €180.00 | |
1126 | CHIR98014 | GSK-3 inhibitor | €99.00 | |
1386 | CHIR99021 | GSK-3 inhibitor | €60.00 | |
2435 | CHIR99021 dihydrochloride | GSK-3 inhibitor | €60.00 | |
2331 | FRAX 486 | Bioavailable, brain penetrating inhibitor of p21-activated kinases (PAKs) | €90.00 | |
2348 | GNE 7915 | Potent, selective, metabolically stable, and brain-penetrable LRRK2 inhibitor | €110.00 | |
2181 | GSK 2578215A | Potent and highly selective LRRK2 inhibitor | €125.00 | |
3627 | Harmine | Potent, selective and ATP-competitive DYRK1A inhibitor | €50.00 | |
2511 | IM 12 | GSK-3β inhibitor attenuating neuronal differentiation of human NPCs | €95.00 | |
2493 | LRRK2-IN-1 | Potent, ATP-competitive and selective inhibitor of LRRK2 | €85.00 | |
5011 | Naive Stem Cell 5i inhibitor Set | Set of five inhibitors for the induction and maintenance of human naive stem cell pluripotency | €200.00 | |
5010 | Naive Stem Cell NHSM inhibitor Set | Set of inhibitors for isolation, generation, derivatization and stabilization of naive hPSCs | €230.00 | |
2546 | PF 06447475 | Potent, selective, brain penetrant, and in vivo active LRRK2 kinase inhibitor | €85.00 | |
3154 | rac-BRD0705 | GSK3α inhibitor | €120.00 | |
1303 | SB 216763 | GSK-3 inhibitor | €85.00 | |
5009 | Stem Cell 4i inhibitor Set | Set of Thiazovivin, SB 431542, PD0325901, and CHIR99021 (inhibitors of ROCK, TGF-β, MEK, and GSK-3 resp.) | €170.00 | |
5007 | Stem Cell 5i inhibitor Set | Set of five inhibitors for neural differentiation of human pluripotent stem cells. | €200.00 | |
2130 | Stem Cell Alternative 2i inhibitor Set | Set of SRC inhibitor CGP77675 (Axon 2097) and GSK-3 inhibitor CHIR99021 (Axon 1386) | €110.00 | |
5006 | Stem Cell CSD inhibitor Set | Set of CHIR99021, SU5402, and DAPT, inhibitors of GSK-3, FGFR, and γ-secretase, resp. | €140.00 | |
2010 | TDZD 8 | Selective and non-ATP-competitive inhibitor of GSK-3β | €90.00 | |
3579 | Tideglusib | GSK-3 inhibitor | €60.00 | |
1562 | TWS 119 | GSK-3β inhibitor | €70.00 |