CNS

The human nervous system is divided into the central nervous system (CNS) and the peripheral nervous system (PNS). The CNS, in turn, is divided into the brain and the spinal cord, which lie in the cranial cavity of the skull and the vertebral canal, respectively. The CNS and the PNS, acting in concert, integrate sensory information and control motor and cognitive functions. Based on its functions, the CNS can be divided into three main functional components: the sensory system, the motor system, and homeostatic and higher brain functions. Cell signaling throughout the CNS occurs by means of neurotransmitters or ions of various kinds interacting at membrane bound receptors and ion channels that, in turn, send the signal through second messenger systems to different compartments of the cell. Malfunctions of the CNS can cause numerous diseases and disorders such as Alzheimer's and Parkinson's disease, multiple sclerosis (MS), anxiety, schizophrenia, and many others. Although many of these failures of the CNS appear to be age related, some occur already in a very early stage of development of the organism, or may even be genetically inherited. The prevention and treatment of neurological disorders represents one of the most difficult and challenging goals of modern medical research.

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Axon ID Name Description From price
1758 (R)-(+)-BAY K 8644 Calcium (Ca2+) channel modulator €115.00
1915 A 803467 Blocker of the voltage-gated Nav1.8 channel €95.00
1113 AM 36 dihydrochloride Na+ channel blocker €145.00
2243 AVE 0118 hydrochloride Potassium channel blocker (Kv1.5 (IKur), Kv4.3 (Ito), Kir3.4 (IKAch), and IKr currents) €120.00
1294 Chromanol 293B KCNQ1 channel blocker €95.00
2458 Clemizole Inhibitor of the transient receptor potential channel TRPC5 €75.00
1899 CNV 1014802 Na+ channel blocker; anti-convulsant €125.00
2548 CNV 1014802 hydrochloride Na+ channel blocker; anti-convulsant €125.00
1868 CRAC inhibitor 44 Potent and selective CRAC ion channel blocker €110.00
1322 DMP 543 K+ channel blocker; Ach release stimulator €90.00
2103 Dofetilide Kv11.1 (hERG) channel blocker €85.00
1448 Felodipine Ca2+ channel blocker €65.00
2064 Glibenclamide potassium salt KATP channel blocker; inhibits SUR1 €50.00
1757 HMR 1098 K+ channel blocker (SUR1/Kir6.2 selective) €90.00
1735 Kv1.3 Channel blocker 42 Kv1.3 potassium channel blocker €110.00

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