CNS

The human nervous system is divided into the central nervous system (CNS) and the peripheral nervous system (PNS). The CNS, in turn, is divided into the brain and the spinal cord, which lie in the cranial cavity of the skull and the vertebral canal, respectively. The CNS and the PNS, acting in concert, integrate sensory information and control motor and cognitive functions. Based on its functions, the CNS can be divided into three main functional components: the sensory system, the motor system, and homeostatic and higher brain functions. Cell signaling throughout the CNS occurs by means of neurotransmitters or ions of various kinds interacting at membrane bound receptors and ion channels that, in turn, send the signal through second messenger systems to different compartments of the cell. Malfunctions of the CNS can cause numerous diseases and disorders such as Alzheimer's and Parkinson's disease, multiple sclerosis (MS), anxiety, schizophrenia, and many others. Although many of these failures of the CNS appear to be age related, some occur already in a very early stage of development of the organism, or may even be genetically inherited. The prevention and treatment of neurological disorders represents one of the most difficult and challenging goals of modern medical research.

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Axon ID Name Description From price
1697 BAY K 8644 Calcium (Ca2+) channel activator (L-type voltage-gated) €95.00
1758 BAY K 8644, (R)-(+)- Calcium (Ca2+) channel modulator €115.00
1759 BAY K 8644, (S)-(-)- Calcium (Ca2+) channel activator (L-type voltage-gated) €115.00
1818 Calhex 231 hydrochloride NAM of the extracellular CaSR €99.00
1732 CaSR antagonist 18c Calcium-sensing receptor (CaSR) antagonist €125.00
2458 Clemizole Inhibitor of the transient receptor potential channel TRPC5 €75.00
1868 CRAC inhibitor 44 Potent and selective CRAC ion channel blocker €110.00
1448 Felodipine Ca2+ channel blocker €65.00
2068 Nifedipine Ca2+ channel blocker (L-type voltage gated) €55.00
1274 PNU 37883 hydrochloride K+ channel blocker (ATP sensitive, vascular) €85.00
1823 Pregabalin Reduces synaptic signaling by binding to α2δ subunits €85.00
1221 SKF 96365 hydrochloride Ca2+ channel blocker €105.00

12 Item(s)

per page
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