CNS

The human nervous system is divided into the central nervous system (CNS) and the peripheral nervous system (PNS). The CNS, in turn, is divided into the brain and the spinal cord, which lie in the cranial cavity of the skull and the vertebral canal, respectively. The CNS and the PNS, acting in concert, integrate sensory information and control motor and cognitive functions. Based on its functions, the CNS can be divided into three main functional components: the sensory system, the motor system, and homeostatic and higher brain functions. Cell signaling throughout the CNS occurs by means of neurotransmitters or ions of various kinds interacting at membrane bound receptors and ion channels that, in turn, send the signal through second messenger systems to different compartments of the cell. Malfunctions of the CNS can cause numerous diseases and disorders such as Alzheimer's and Parkinson's disease, multiple sclerosis (MS), anxiety, schizophrenia, and many others. Although many of these failures of the CNS appear to be age related, some occur already in a very early stage of development of the organism, or may even be genetically inherited. The prevention and treatment of neurological disorders represents one of the most difficult and challenging goals of modern medical research.

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Axon ID Name Description From price
1125 BACE-1 Inhibitor BACE 1 inhibitor €110.00
2957 BACE-2 Inhibitor Potent and highly selective BACE 2 inhibitor  Recently added €135.00
2117 Begacestat Selective γ-secretase inhibitor (GSI) €85.00
2158 Boc-D-FMK Broad spectrum caspase inhibitor €110.00
1487 BZ, γ-Secretase Inhibitor γ-Secretase inhibitor (GSI) €85.00
1484 DAPT γ-Secretase inhibitor €90.00
1488 DBZ, γ-Secretase Inhibitor γ-Secretase inhibitor (GSI) €70.00
1375 Ivachtin Caspase-3 inhibitor €55.00
2869 LX2343 BACE 1 inhibitor €125.00
2225 LY 2811376 The first orally available non-peptidic BACE 1 inhibitor €125.00
1964 LY 2886721 hydrochloride BACE 1 inhibitor €105.00
1743 PAC 1 Procaspase activating compound 1 €80.00
2521 RO 4929097 Potent γ-secretase inhibitor (GSI) targeting Notch signaling in various tumor cells €135.00
2159 Z-VAD-FMK Pan-caspase inhibitor with in vivo activity Inquire

14 Item(s)

per page
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