CNS
The human nervous system is divided into the central nervous system (CNS) and the peripheral nervous system (PNS). The CNS, in turn, is divided into the brain and the spinal cord, which lie in the cranial cavity of the skull and the vertebral canal, respectively. The CNS and the PNS, acting in concert, integrate sensory information and control motor and cognitive functions. Based on its functions, the CNS can be divided into three main functional components: the sensory system, the motor system, and homeostatic and higher brain functions. Cell signaling throughout the CNS occurs by means of neurotransmitters or ions of various kinds interacting at membrane bound receptors and ion channels that, in turn, send the signal through second messenger systems to different compartments of the cell. Malfunctions of the CNS can cause numerous diseases and disorders such as Alzheimer's and Parkinson's disease, multiple sclerosis (MS), anxiety, schizophrenia, and many others. Although many of these failures of the CNS appear to be age related, some occur already in a very early stage of development of the organism, or may even be genetically inherited. The prevention and treatment of neurological disorders represents one of the most difficult and challenging goals of modern medical research.
Axon ID | Name | Description | From price | |
---|---|---|---|---|
1190 | 2-Chloroadenosine | Adenosine A1 and A2A agonist | €65.00 | |
1188 | Adenosine amine congener | Adenosine A1 agonist | €125.00 | |
4069 | AZD4635 | Potent and selective adenosine A2A antagonist | Inquire | |
2317 | BAY 60-6583 | Potent and highly selective A2BAR (Adenosine) agonist | €125.00 | |
1319 | CGS 21680 hydrochloride | Adenosine A2A agonist | €95.00 | |
3825 | Cordycepin | Nucleoside analogue; Anticancer and anti-inflammatory agent | €60.00 | |
2283 | Desmethyl SCH 442416 | Radioligand precursor of the adenosine A2A antagonist SCH 442416 | €300.00 | |
3847 | DPTN | Highly potent A3 receptor antagonist | €130.00 | |
1287 | GR 79236 | Adenosine A1 agonist | €120.00 | |
1423 | Istradefylline | Adenosine A2A antagonist | €75.00 | |
3684 | MRS 1220 | Potent and selective hA3 receptor antagonist | €140.00 | |
2076 | MRS 1523 | Adenosine A3 receptor antagonist | €130.00 | |
3826 | NUC-7738 | Prodrug of Cordycepin; Anticancer agent | €160.00 | |
4132 | PBF-509 | Selective Adenosine 2A receptor antagonist | Inquire | |
1603 | Rolofylline | Adenosine A1 antagonist | €90.00 | |
1852 | Rolofylline metabolite M1-cis | Adenosine A1 antagonist | €105.00 | |
1851 | Rolofylline metabolite M1-trans | Adenosine A1 antagonist | €105.00 | |
1264 | SCH 442416 | Adenosine A2A antagonist | €90.00 | |
1253 | SCH 58261 | Adenosine A2A antagonist | €90.00 | |
1265 | SDZ-WAG 994 | Adenosine A1 agonist | €125.00 | |
1193 | UK 432097 | Adenosine A2A agonist | €125.00 | |
3519 | VCP171 | Positive allosteric modulator (PAM) of A1 receptors | €120.00 | |
3626 | Vipadenant | Potent, selective and orally active adenosine A2A antagonist | €90.00 | |
4001 | ZM241385 | Potent and selective adenosine A2A antagonist | €110.00 |