Bulk Inquiry
(+)-PHNO hydrochloride
- Naxagolide - Dopazinol
Axon 1071
- Parent CAS: 88058-88-2
- Optical Purity: >98% e.e.
- Soluble in water and DMSO
- MF: C15H21NO2.HCl
- MW: 283.79
Description
Very potent and selective D2 agonist, more active enantiomer. Note: Appropriate chiral precursor(s) for making D2 radiotracer, [11C]-(+)-PHNO, can be provided on request.
More Information
| Parent CAS No. | 88058-88-2 |
|---|---|
| Chemical Name | (4aR,10bR)-4-Propyl-3,4,4a,5,6,10b-hexahydro-2H-naphtho[1,2-b][1,4]oxazin-9-ol hydrochloride |
| SMILES | C1(O)=CC2[C@H]3OCCN(CCC)[C@@H]3CCC=2C=C1.Cl |&1:4,12,r| |
| MFCD | N.A. |
| InChi | InChI=1S/C15H21NO2.ClH/c1-2-7-16-8-9-18-15-13-10-12(17)5-3-11(13)4-6-14(15)16;/h3,5,10,14-15,17H,2,4,6-9H2,1H3;1H/t14-,15-;/m1./s1 |
| InChiKey | NNEACMQMRLNNIL-CTHHTMFSSA-N |
| CID | 57532 |
| Short Description | D2 agonist |
References
- Martin et al. Selectivity of (+)-4-propyl-9-hydroxynaphthoxazine [(+)-PHNO] for dopamine receptors in vitro and in vivo. J. Pharmacol. Exp. Ther. 1985, 233, 2, 395-401.
- N Ginovart et al. Binding characteristics and sensitivity to endogenous dopamine of [11C]-(+)-PHNO, a new agonist radiotracer for imaging the high-affinity state of D2 receptors in vivo using positron emission tomography. J. Neurochem. 2006, 97, 1089-1103
- P Seeman et al. Dopamine receptors labelled by PHNO. Synapse. 1993, 14(4), 254-62.
- A Graff-Guerrero et al. The effect of antipsychotics on the high-affinity state of D2 and D3 receptors: a positron emission tomography study With [11C]-(+)-PHNO. Arch Gen Psychiatry. 2009, 66(6), 606-15.
Related Products
Other Categories
Get a Quote for
Loading...
Are you sure you would like to remove this item from the shopping cart?
This item is a part of the approved quote. Removing it will remove all quote items from the cart.