Oxygenases
Oxygenases (subclass of oxidoreductases; EC 1.) are enzymes that incorporate oxygen atoms from O2 into the oxidized products. Dioxygenases are uncommon enzymes that incorporate both atoms of O2 into one substrate. Besides the large family of cytochrome P450-related (CYP) enzymes, this class of oxidoreductases also includes the well-known family of cyclooxygenases (COX, officially known as prostaglandin-endoperoxide synthase (PTGS))[1], but also histone demethylases (JMJD), desaturases and aromatases, and many others.
[1] Cyclooxygenase enzymes: regulation and function. F.A. Fitzpatrick. Curr. Pharm. Des. 2004, 10, 577-588.
| Axon ID | Name | Description | From price | |
|---|---|---|---|---|
| 1873 | Abiraterone | Inhibitor of CYP17A1 | €90.00 | |
| 1874 | Abiraterone acetate | Prodrug of Abiraterone; Inhibitor of CYP17A1 | €90.00 | |
| 2288 | ATB 346 | Orally active hydrogen sulfide-releasing cyclooxygenase inhibitor | €110.00 | |
| 2306 | Bizine | Potent LSD1 inhibitor with selectivity over MAO-A/B, and LSD2 | €120.00 | |
| 2489 | Brassinin | Dual IDO1/STAT3 inhibitor with antifungal and anticancer activity | €75.00 | |
| 1919 | Celecoxib | Selective COX-2 inhibitor | €50.00 | |
| 2622 | CPI 4203 | Selective inhibitor of KDM5 demethylases (H3K4 specific) | €85.00 | |
| 2573 | CPI 455 | Selective inhibitor of KDM5 demethylases (H3K4 specific) | €95.00 | |
| 1815 | Delavirdine | NNRT inhibitor (HIV-1) | €90.00 | |
| 1977 | DMOG | Cell-permeable HIF-PHD inhibitor with pro-angiogenic and -osteogenic properties | €65.00 | |
| 2045 | Exemestane | Irreversible steroidal aromatase (CYP19A1) inhibitor | €80.00 | |
| 2570 | FG-2216 | Orally active HIF-PHD inhibitor that increases plasma EPO levels in vivo | €95.00 | |
| 2588 | FG-4592 | New-generation oral HIF-PHD inhibitor | €55.00 | |
| 2105 | Fluconazole | Fungal CYP450 enzyme 14α-demethylase inhibitor | €60.00 | |
| 1934 | GSK J1 | Histone demethylase JMJD3/UTX inhibitor | €105.00 | |