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Exemestane
- Aromasin - FCE 24304
Axon 2045
CAS:
107868-30-4
- Optical Purity: Optically pure
- Soluble in DMSO and EtOH
- MF: C20H24O2
- MW: 296.4
Description
Orally active, irreversible steroidal aromatase inhibitor (IC50 = 20 nM). Destabilizes aromatase and lowers estrogen levels; breast cancer therapy.
More Information
| Parent CAS No. | 107868-30-4 |
|---|---|
| Chemical Name | (8R,9S,10R,13S,14S)-10,13-dimethyl-6-methylene-7,8,9,10,11,12,13,14,15,16-decahydro-3H-cyclopenta[a]phenanthrene-3,17(6H)-dione |
| extra_info | . |
| SMILES | C1(=O)C=C2[C@](C)(C=C1)[C@]1([H])[C@]([H])([C@@]3([H])[C@@](CC1)(C)C(=O)CC3)CC2=C |&1:4,8,10,12,14,r| |
| MFCD | N.A. |
| InChi | InChI=1S/C20H24O2/c1-12-10-14-15-4-5-18(22)20(15,3)9-7-16(14)19(2)8-6-13(21)11-17(12)19/h6,8,11,14-16H,1,4-5,7,9-10H2,2-3H3/t14-,15-,16-,19+,20-/m0/s1 |
| InChiKey | BFYIZQONLCFLEV-DAELLWKTSA-N |
| CID | 60198 |
| Short Description | Aromatase inhibitor |
References
- D Giudici et al. 6-Methylenandrosta-1,4-diene-3,17-dione (FCE 24304): A new irreversible aromatase inhibitor. J. Steroid Biochem. 1988, 30 (1–6), 391–394.
- N Mauras et al. Pharmacokinetics and Dose Finding of a Potent Aromatase Inhibitor, Aromasin (Exemestane), in Young Males. J. Clin. Endocrinol. Metab. 2003, 88(12), 5951–5956.
- RC Coombes et al. A Randomized Trial of Exemestane after Two to Three Years of Tamoxifen Therapy in Postmenopausal Women with Primary Breast Cancer. N. Engl. J. Med. 2004, 350, 1081-1092.
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