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Anastrozole
- Arimidex - ZD1033 - ICI D1033
Axon 3316
CAS:
120511-73-1
Purity:
99%
- Soluble in DMSO
- MF: C17H19N5
- MW: 293.37
Description
Anastrozole is a potent, highly selective, and orally active fourth-generation aromatase inhibitor (IC50 value of 15 nM) with no intrinsic hormonal activities.
More Information
| Parent CAS No. | 120511-73-1 |
|---|---|
| Chemical Name | 2,2'-(5-((1H-1,2,4-Triazol-1-yl)methyl)-1,3-phenylene)bis(2-methylpropanenitrile) |
| SMILES | C1C(CN2N=CN=C2)=CC(C(C)(C#N)C)=CC=1C(C)(C#N)C |
| MFCD | MFCD00866298 |
| InChi | InChI=1S/C17H19N5/c1-16(2,9-18)14-5-13(8-22-12-20-11-21-22)6-15(7-14)17(3,4)10-19/h5-7,11-12H,8H2,1-4H3 |
| InChiKey | YBBLVLTVTVSKRW-UHFFFAOYSA-N |
| CID | 2187 |
| Short Description | Aromatase inhibitor |
References
- PV Plourde et al. Arimidex: a potent and selective fourth-generation aromatase inhibitor. Breast Cancer Res Treat. 1994;30(1):103-11.
- M Dukes et al. The preclinical pharmacology of "Arimidex" (anastrozole; ZD1033)--a potent, selective aromatase inhibitor. J Steroid Biochem Mol Biol. 1996 Jul;58(4):439-45.
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