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Flurbiprofen
- Soluble in DMSO
- MF: C15H13FO2
- MW: 244.26
Description
Flurbiprofen is a cyclo-oxygenase (COX) inhibitor with IC50 values of 0.1 and 0.4 μM for hCOX-1 and hCOX-2, respectively. Non-steroidal anti-inflammatory drug (NSAID).
More Information
| Parent CAS No. | 5104-49-4 |
|---|---|
| Chemical Name | 2-(2-Fluorobiphenyl-4-yl)propanoic acid |
| SMILES | C1C=CC(C2C=CC(C(C(O)=O)C)=CC=2F)=CC=1 |
| MFCD | MFCD00079303 |
| InChi | InChI=1S/C15H13FO2/c1-10(15(17)18)12-7-8-13(14(16)9-12)11-5-3-2-4-6-11/h2-10H,1H3,(H,17,18) |
| InChiKey | SYTBZMRGLBWNTM-UHFFFAOYSA-N |
| CID | 3394 |
| Short Description | COX inhibitor |
References
- LH Rome et al. Structural requirements for time-dependent inhibition of prostaglandin biosynthesis by anti-inflammatory drugs. Proc Natl Acad Sci U S A. 1975;72(12):4863‐4865.
- RN Brogden et al. Flurbiprofen: a review of its pharmacological properties and therapeutic use in rheumatic diseases. Drugs. 1979;18(6):417-438.
- JK Gierse et al. Expression and selective inhibition of the constitutive and inducible forms of human cyclo-oxygenase. Biochem J. 1995;305
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