Oxygenases

Oxygenases (subclass of oxidoreductases; EC 1.) are enzymes that incorporate oxygen atoms from O2 into the oxidized products. Dioxygenases are uncommon enzymes that incorporate both atoms of O2 into one substrate. Besides the large family of cytochrome P450-related (CYP) enzymes, this class of oxidoreductases also includes the well-known family of cyclooxygenases (COX, officially known as prostaglandin-endoperoxide synthase (PTGS))[1], but also histone demethylases (JMJD), desaturases and aromatases, and many others.


[1] Cyclooxygenase enzymes: regulation and function. F.A. Fitzpatrick. Curr. Pharm. Des. 2004, 10, 577-588.

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Axon ID Name Description From price
2489 Brassinin Dual IDO1/STAT3 inhibitor with antifungal and anticancer activity €75.00
1733 INCB 024360 Potent inhibitor of indoleamine 2,3-dioxygenase-1 (IDO1) €105.00
2215 INCB 024360-analog Potent inhibitor of indoleamine 2,3-dioxygenase-1 (IDO1) €85.00
2139 RO 61-8048 Inhibitor of kynurenine-3-monooxygenase (KMO) €95.00
2118 UPF 648 Potent inhibitor of kynurenine-3-monooxygenase (KMO) €115.00

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