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Brassinin
- Soluble in DMSO
- MF: C11H12N2S2
- MW: 236.36
Description
Brassinin is a bioavailable dithiocarbamate natural-product derivative with reported activity against indoleamine 2,3-dioxygenase (IDO1) and STAT3 signaling. It suppresses kynurenine-pathway and inflammatory oncogenic signaling in reported models.
IDO1 regulates tryptophan catabolism and immune suppression through kynurenine production, while STAT3 supports tumor-promoting inflammation and survival. Brassinin is useful for studying immunometabolic and STAT3-linked anticancer mechanisms.
Key Features
- Reported IDO1 inhibitor
- Reported Ki: 28 µM for human IDO
- Suppresses constitutive and IL-6-induced STAT3 signaling
- Bioavailable dithiocarbamate with anticancer and antifungal activity
Applications
- IDO1/kynurenine pathway research
- Cancer immunometabolism studies
- STAT3 inflammatory signaling assays
- Natural product anticancer pharmacology
More Information
| Parent CAS No. | 105748-59-2 |
|---|---|
| Chemical Name | methyl (1H-indol-3-yl)methylcarbamodithioate |
| SMILES | C(=S)(SC)NCC1C2=C(NC=1)C=CC=C2 |
| MFCD | MFCD01632490 |
| InChi | InChI=1S/C11H12N2S2/c1-15-11(14)13-7-8-6-12-10-5-3-2-4-9(8)10/h2-6,12H,7H2,1H3,(H,13,14) |
| InChiKey | QYKQWFZDEDFELK-UHFFFAOYSA-N |
| CID | 3035211 |
| Short Description | Dual IDO1/STAT3 inhibitor |
References
- T. Banerjee et al. A key in vivo antitumor mechanism of action of natural product-based brassinins is inhibition of indoleamine 2,3-dioxygenase. Oncogene. 2008 May 1;27(20):2851-7.
- P. Gaspari et al. Structure-activity study of brassinin derivatives as indoleamine 2,3-dioxygenase inhibitors. J Med Chem. 2006 Jan 26;49(2):684-92.
- J.H. Lee et al. Brassinin inhibits STAT3 signaling pathway through modulation of PIAS-3 and SOCS-3 expression and sensitizes human lung cancer xenograft in nude mice to paclitaxel. Oncotarget. 2015 Mar 20;6(8):6386-405.
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