Inhibitor of 15-lipoxygenase-1 (15-LOX-1) with an IC50 value of 0.19 μM. 15-LOX-1 inhibitor i472 shows an ability to protect RAW 264.7 macrophages from LPS-induced cell death. Furthermore, i472 is shown to provide significant inhibition of NF-κB transcriptional activation upon LPS/INFγ stimulation, to downregulate the expression of the NF-κB related gene iNOS, to provide dose-dependent inhibition of NO production and to reduce lipid peroxidation in RAW macrophages.
*Sold in collaboration with RuG (University of Groningen)

KEYWORDS: 15-LOX-1 inhibitor i472 | supplier | Lipoxygenase inhibitor | 15-LOX-1 inhibitor i 472 | 15-LOX-1 inhibitor i-472 | CAS [2349374-37-2] | Fatty acid (Arachidonic acid) | LOX | Inhibitor | Enzymes