15-LOX-1 inhibitor i472

Based on 1 reference(s) in Google Scholar 8 10 1

Axon 2989

CAS [2349374-37-2]

MF C22H21ClN2O4
MW 412.87

  • Purity: 98%
  • Soluble in DMSO

15-LOX-1 inhibitor i472

Description

Inhibitor of 15-lipoxygenase-1 (15-LOX-1) with an IC50 value of 0.19 μM. 15-LOX-1 inhibitor i472 shows an ability to protect RAW 264.7 macrophages from LPS-induced cell death. Furthermore, i472 is shown to provide significant inhibition of NF-κB transcriptional activation upon LPS/INFγ stimulation, to downregulate the expression of the NF-κB related gene iNOS, to provide dose-dependent inhibition of NO production and to reduce lipid peroxidation in RAW macrophages.
*Sold in collaboration with RuG (University of Groningen)

KEYWORDS: 15-LOX-1 inhibitor i472 | supplier | Lipoxygenase inhibitor | 15-LOX-1 inhibitor i 472 | 15-LOX-1 inhibitor i-472 | CAS [2349374-37-2] | Fatty acid (Arachidonic acid) | LOX | Inhibitor | Enzymes

Inhibitor of 15-lipoxygenase-1 (15-LOX-1)

Chemical name

(E)-Ethyl 6-chloro-3-(3-(2-methoxybenzylamino)-3-oxoprop-1-enyl)-1H-indole-2-carboxylate

Source information

Sold in collaboration with RuG (University of Groningen)

Parent CAS No.

[2349374-37-2]

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The purity of Axon Ligands™ is confirmed by HPLC-MS, 1H-NMR and/or microanalysis. Analytical data are available upon request.

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