Diethylcarbamazine citrate (DEC) is a filaricidal drug. Pharmacological studies showed that DEC interferes with arachidonic acid metabolism, acting as an anti-inflammatory drug. It has been found that DEC blocks a number of steps in both the cyclooxygenase (COX) and lipoxygenase pathways, including the inhibition of leucocyte chemotaxis, granulocyte degranulation, and peripheral vasodilation.

KEYWORDS: Diethylcarbamazine citrate | supplier | Filaricidal drug | Hetrazan | DEC | CAS [1642-54-2] | [90-89-1] | Fatty acid (Arachidonic acid) | COX | Inhibitor | Enzymes | Filarial worm | Lymphatic filariasis